Document 2651
 DOCN  M94A2651
 TI    Clinical markers in the diagnosis of perinatal HIV infection.
 DT    9412
 AU    Arabe J; Rubini NP; Guimaraes MD; Crasto MC; Sion FS; Morais-de-Se CA;
       Gaffree & Guinle University Hospital, University of Rio de; Janeiro,
       Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):256 (abstract no. PB0452). Unique
       Identifier : AIDSLINE ICA10/94369924
 AB    OBJECTIVE: To identificate clinical markers usefull in the diagnosis of
       vertically acquired HIV infection. METHODS: We retrospectively analysed
       89 infants born to HIV-infected mothers between Aug 86 and Jun 92. All
       the infants were HIV-antibody positive at birth and had clinical
       follow-up from birth to 18 months of age. HIV infection diagnostic was
       according to CDC criteria. The clinical variables analysed were:
       persistent generalized lymphadenopathy (PGL), hepatomegaly/splenomegaly
       (HS), diarrhea persistent or recurrent (DP/R), parotiditis (PR),
       dermatitis (DR), bacterial pneumonia (BP), severe bacterial infection
       (SBI), Tuberculosis (TB), thrush (TH), and failure-to-thrive (FTT). The
       statistic analysis includes the evaluation of the sensitivity,
       specificity, positive and negative preditive values (PPV and NPV).
       RESULTS: Among the analysed infants 38 (42.7%) were infected by HIV and
       51 (57.3%) were uninfected. Analysis of sensitivity, specificity, PPV
       and NPV of the clinical findings are demonstrated in the table bellow:
       TABULAR DATA, SEE ABSTRACT VOLUME. CONCLUSIONS: 1) Clinical variables
       analysed didn't demonstrate diagnostic value in a isolated way. 2) The
       presence of two clinical findings concomitantly gives a significative
       increase the diagnostic acuracity.
 DE    AIDS-Related Opportunistic Infections/*DIAGNOSIS/TRANSMISSION  Brazil
       *Developing Countries  Female  Follow-Up Studies  Human  HIV
       Infections/*DIAGNOSIS/TRANSMISSION  HIV
       Seropositivity/*DIAGNOSIS/TRANSMISSION  Infant  Infant, Newborn  Male
       Pregnancy  MEETING ABSTRACT

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