Document 2655
 DOCN  M94A2655
 TI    Diagnosis of perinatally acquired HIV-1 infection by IgA EIA test.
 DT    9412
 AU    Liberatore D; Avila M; Calarota S; Libonatti O; Martinez Peralta L;
       National Reference Centre for AIDS, Buenos Aires, Argentina.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):255 (abstract no. PB0450). Unique
       Identifier : AIDSLINE ICA10/94369920
 AB    OBJECTIVE: To evaluate the clinical utility of detection of anti-HIV-1
       IgA antibody by a serological assay for the early diagnosis of
       perinatally acquired HIV-1 infection. METHODS: Sera were obtained from
       45 infants born to HIV-1 infected mothers and tested for HIV IgA
       antibodies by an ELISA test after removal of IgG with recombinant
       protein G. Infants were classified according to age and infection status
       after 15 months of age; 24 were classified as HIV infected children and
       21 as uninfected (CDC, 1987). RESULTS: The HIV-IgA assay was positive in
       15 infected children between 6 and 12 months and in 6 infected children
       older than 12 months but under 18 months. Nineteen serum samples from
       uninfected children under 15 months of age were negative by the HIV-1
       IgA assay. False negative results were found in 3 infected children of
       1, 6 and 8 months of age. False positive results were found in 2
       uninfected children of 8 and 9 months of age. CONCLUSIONS: The detection
       of IgA HIV antibodies is an effective method for early diagnosis of
       HIV-infected infants in comparison with conventional IgG HIV antibody
       tests. It is a simple and inexpensive method that could be used in both
       developed and developing countries.
 DE    Argentina  AIDS Serodiagnosis/*METHODS  *Developing Countries  Female
       Follow-Up Studies  Human  HIV Antibodies/*BLOOD  HIV
       Seropositivity/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION  HIV-1/*IMMUNOLOGY
       IgA/*BLOOD  *Immunoenzyme Techniques  Infant  Infant, Newborn  Male
       Predictive Value of Tests  Pregnancy  MEETING ABSTRACT

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