Document 2656
 DOCN  M94A2656
 TI    Tuberculosis in Brazilian HIV-infected children report 10 cases.
 DT    9412
 AU    Hamamoto LA; Sato H; Sakane PT; Kamikawa J; Costa PS; Biondillo TA;
       Marques HH; Dept. Pediatrics, Univ. Sao Paulo, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):254 (abstract no. PB0445). Unique
       Identifier : AIDSLINE ICA10/94369919
 AB    Since 1985 our institution is attending HIV infected children (n = 145
       cases, P2 or P1B) and because the high incidence of tuberculosis in our
       State (50 cases/10(5) inhabitants) the authors have persistent suspicion
       for tuberculosis when HIV children have respiratory symptons. METHODS:
       The authors designed a protocol for evaluation of clinical, laboratorial
       and epidemiologic features for children with pulmonary manifestations
       and/or adenopathy associated with fever without response to conventional
       antimicrobial therapy. Culture and acid-fast stain of gastric aspirates,
       sputum, tracheal aspiration and/or bronchoalveolar lavage, skin testing
       (PPD) and clinical response to antituberculous drugs were included.
       RESULTS: Tuberculousis was diagnosed in ten HIV patients, despite five
       of then were vaccinated perinatally. Seven of then had positive culture
       for M. tuberculosis and the others had clinical and epidemiological
       features and clinical response to antituberculous therapy. Side effects
       were observed in only two children. Seven children had pulmonary
       manifestation, four had adenopathy and one had disseminated
       tuberculosis. Two children died and the other improved with therapy.
       CONCLUSION: Tuberculosis is a highly significant coinfection in HIV
       infected children, specially in developing countries.
 DE    Antitubercular Agents/ADVERSE EFFECTS/THERAPEUTIC USE  AIDS-Related
       Opportunistic Infections/*DIAGNOSIS/DRUG THERAPY  Brazil  Child
       *Developing Countries  Human  HIV Infections/*DIAGNOSIS/DRUG THERAPY
       Tuberculosis, Pulmonary/*DIAGNOSIS/DRUG THERAPY  MEETING ABSTRACT

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