Document 2663
 DOCN  M94A2663
 TI    Arteriopathy in children with AIDS.
 DT    9412
 AU    Lanjewar DN; Maheshwari MB; Dept. of Pathology, Grant Medical College,
       J.J. Hospital, Bombay.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):253 (abstract no. PB0442). Unique
       Identifier : AIDSLINE ICA10/94369912
 AB    OBJECTIVE--To study changes of arteriopathy in small and medium sized
       arteries and other associated lesions in children with AIDS.
       METHODS--Autopsy study of children with AIDS was carried out. Histology
       was studied by H & E and special stains. The pathognomonic features of
       arteriopathy were specifically looked for along with a note of other
       AIDS associated lesions. RESULTS--Three out of four children showed
       histomorphological features characteristic of arteriopathy which
       consisted of fibrosis of intima and media with luminal narrowing and
       fragmentation of internal elastic lamina. Calcification was not noted in
       any of our cases. The arterial lesions were seen in lung, heart, kidney,
       liver, spleen, lymphnodes and thymus. Other noted lesions were pulmonary
       lymphoid hyperplasia, disseminated cytomegalovirus and candidial
       infections. CONCLUSION--Arteriopathy is a distinct entity and the
       pathogenesis of it is believed to be exposure to endogenous and
       exogenous elastases due to repeated opportunistic and bacterial
       infections. High degree of suspicion is required to diagnose these
       lesions antemortem.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  Arteries/PATHOLOGY
       AIDS-Related Opportunistic Infections/PATHOLOGY  Child  Elastic
       Tissue/PATHOLOGY  Fibromuscular Dysplasia/*PATHOLOGY  Human  MEETING
       ABSTRACT

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