Document 2676
 DOCN  M94A2676
 TI    Risk factors for HIV seroconversion among injecting drug users in
       Montreal: the Saint-Luc cohort experience.
 DT    9412
 AU    Lamothe F; Bruneau J; Soto J; Lachance N; Franco E; Vincelette J; Fauvel
       M; Hopital Saint-Luc, Canada.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):25 (abstract no. 074C). Unique
       Identifier : AIDSLINE ICA10/94369899
 AB    OBJECTIVES: To evaluate HIV seroconversion rates and risk factors in an
       open dynamic cohort of injecting drug users (IDUs) in Montreal. METHODS:
       Consenting IDUs (all recent injectors) were recruited from the street
       and treatment centers in a follow-up cohort. Information and HIV
       serology were obtained at each visit. Univariate actuarial analysis of
       seroconversion was performed using Kaplan-Meier life time estimators.
       RESULTS: From 1988/9 to 1993/2, 55 of 608 negative subjects
       seroconverted. Total follow-up was 874 person-years for an incidence
       rate per 100 person-years of 6.3% (95% IC: 4.7-8.2). For 3 consecutive
       18 months periods, incidence rose from 4.8% (88/9-90/2), 7.5%
       (90/3-91/8) to 9.8% (after 91/9) (p = 0.046, Log-rank test). Entry
       factors associated with conversion were: street recruitment, previous
       imprisonment, cocaine preference, more than 15 injections (last 28
       days), attending a needle exchange program at least once, 2 or more
       sharing partners, sharing with an HIV+/AIDS partner, and having
       HIV+/AIDS acquaintances (all p < 0.05, Log-rank test). Factors not
       associated were: sex, booting fresh blood, injecting in shooting
       galleries, sexual orientation, prostitution and number of sexual
       partners. CONCLUSION: HIV infection seems to progress among IDUs
       recruited. Seroconversion is associated with needle sharing behaviours
       in spite of risk knowledge and relative availability of sterile
       equipment. More research is needed on impulsive determinants of sharing
       behaviours.
 DE    Actuarial Analysis  Cohort Studies  Female  Human  HIV
       Infections/TRANSMISSION  HIV Seropositivity/*EPIDEMIOLOGY  Incidence
       Male  Needle Sharing  Quebec/EPIDEMIOLOGY  Risk Factors  Sex Behavior
       Substance Abuse, Intravenous/*COMPLICATIONS  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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