Document 2726
 DOCN  M94A2726
 TI    Detection of HIV-2 antibodies in saliva.
 DT    9412
 AU    Fang C; Hofman L; Lugalia L; Saliva Diagnostic Systems, Inc. (SDS),
       Vancouver, WA 98682.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):239 (abstract no. PB0385). Unique
       Identifier : AIDSLINE ICA10/94369849
 AB    Although the presence of HIV-1 antibodies in saliva of infected patients
       has been widely documented, few publications refer to HIV-2 antibodies.
       Results on saliva from 18 HIV-2 infected individuals are described here.
       Saliva and serum specimens were collected from five known HIV-2 infected
       patients in the United States but of West African origin. Saliva was
       collected using the Omni-SAL collection device (Saliva Diagnostic
       Systems, Inc., Vancouver, WA). Abbott HIVAB HIV-1 EIA, BioChem
       ImmunoSystems Detect HIV-1/-2 EIA, Genetic Systems HIV-1/HIV-2 EIA and
       HIV-2 EIA, and Waldheim Pharmazeutika Fluorognost HIV-1 IFA and HIV-2
       IFA were performed on all serum and saliva specimens. In addition,
       Orgenics ImmunoComb BiSpot HIV-1 and HIV-2 was performed on saliva
       specimens. Testing procedures had been optimized for saliva. All saliva
       and serum specimens were positive by HIV-2 and HIV-1/2 assays. Cross
       reactivity with HIV-1 was observed in all sera but only in 40% of saliva
       specimens. Serum and saliva paired specimens were collected from an
       additional 13 HIV-2 infected individuals in the Ivory Coast. All serum
       specimens were shown to be positive for HIV-2 antibodies with Cambridge
       Biotech HIV-2 Western blot assay. Saliva specimens were tested with the
       Genetic Systems HIV-2 EIA, using an optimized in-house protocol. Sera
       were tested using the manufacturers protocol. All were positive. In
       summary, saliva from all HIV-2 infected individuals contained HIV-2
       antibodies as measured by EIA and IFA.
 DE    Comparative Study  Cote d'Ivoire  Cross Reactions  Human  HIV
       Antibodies/*ANALYSIS  HIV Seropositivity/*DIAGNOSIS/IMMUNOLOGY
       HIV-1/IMMUNOLOGY  HIV-2/*IMMUNOLOGY  Immunoenzyme Techniques  Predictive
       Value of Tests  Saliva/*IMMUNOLOGY  United States  MEETING ABSTRACT

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