Document 2743
 DOCN  M94A2743
 TI    Antibodies to HIV-1 nef (P27) on the different stages of HIV infection.
 DT    9412
 AU    Vlassov N; Noskova O; Smolskaya T; St. Petersburg Pasteur Institute,
       Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):235 (abstract no. PB0368). Unique
       Identifier : AIDSLINE ICA10/94369832
 AB    OBJECTIVE: Antibodies to HIV-1 nef gene products were studied in sera of
       65 adults and 67 children with HIV infection. Persons with asymptomatic
       infection prevailed in adult group (83.0%) and with P2A stage--in
       children group (73.1%). METHODS: Test-system Blot-HIV (line-blot enzyme
       immunoassay) was used to detect antibodies to structural proteins and to
       nef gene products. RESULTS: Antibodies to nef gene products were
       detected in 24.6% of adults and in 32.8% of children. Positive results
       were mainly found in adults with PGL (28.9%) and realy in patients with
       ARC and AIDS (9.1%). Positive results were found in 38.7% children with
       stage P2A and in 16.7% of children with ARC or AIDS. In 5 patients with
       rapid progression of one stage to other we failed to detect antibodies
       to nef gene products during the first and repeated test. Positive
       results correlated with the stable phase of HIV infection. In cases with
       negative prognostic clinical signs (thrombocytopenia, anemia, loss of
       weight etc.) antibodies to nef gene products were detection only in
       0-15.8% of cases. At the same time we detected these antibodies in
       16.7-23.3% of patients without such symptoms. DISCUSSION AND CONCLUSION:
       Our preliminary studies demonstrated the regularity in dynamics of
       antibodies to nef gene products. It is possible that this marker has
       prognostic value in this infection.
 DE    Acquired Immunodeficiency Syndrome/CLASSIFICATION/DIAGNOSIS/  IMMUNOLOGY
       Adult  AIDS-Related Complex/CLASSIFICATION/DIAGNOSIS/IMMUNOLOGY  Child
       Female  Genes, nef/*IMMUNOLOGY  Human  HIV Antibodies/*ANALYSIS  HIV
       Infections/CLASSIFICATION/*DIAGNOSIS/IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Male
       Prognosis  MEETING ABSTRACT

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