Document 2772
 DOCN  M94A2772
 TI    Use of agglutination test for the determination of salivary HIV-1
       antibodies.
 DT    9412
 AU    Castillo Torres NP; Barriga AG; Hospital Infectologia Centro Medico La
       Raza, Mexico, D.F.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):228 (abstract no. PB0343). Unique
       Identifier : AIDSLINE ICA10/94369803
 AB    OBJECTIVE: To demonstrate that saliva samples collected with a special
       device (Omni-Sal) can be tested accurately with a gelatin agglutination
       test (Serodia) for antibodies to HIV-1 in a clinical setting. METHODS:
       Matched serum and saliva specimens were collected from 150 persons
       including 75 known HIV-1 positive patients, 51 having diverse
       infectious, metabolic, hematologic and autoimmune diseases and 24
       healthy individuals. All saliva specimens were obtained using the
       Omni-Sal collection device. All specimens were assayed with the Serodia
       HIV-1 test using a-minor modification of the assay procedure. RESULTS:
       Serum and saliva results were in 96.7% agreement when
       minor-modifications were performed to the Serodia procedure for serum,
       in any case there were false negative results with saliva or serum
       samples. CONCLUSIONS: Saliva obtained with the Omni-Sal device can be
       tested for HIV-1 antibodies using the serodia agglutination test
       following minor-modifications of the assay procedure recommended for
       serum samples.
 DE    *Agglutination Tests  Autoimmune Diseases/IMMUNOLOGY  Comparative Study
       Evaluation Studies  False Negative Reactions  Human  HIV
       Antibodies/*ANALYSIS/BLOOD  HIV Infections/*DIAGNOSIS  HIV-1/*IMMUNOLOGY
       Infection/IMMUNOLOGY  Sensitivity and Specificity  Specimen
       Handling/*INSTRUMENTATION  MEETING ABSTRACT

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