Document 2774
 DOCN  M94A2774
 TI    Studies on the HIV-specific IGA antibodies in sera and saliva.
 DT    9412
 AU    Yasuda S; Iwasaki M; Honda M; Oka S; Takemori T; Tsunetsugu-Yokota Y;
       Dept. of Immunol., AIDS RC, National Institute of Health, Tokyo,; Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):228 (abstract no. PB0342). Unique
       Identifier : AIDSLINE ICA10/94369801
 AB    OBJECTIVE: To evaluate the diagnostic value of the detection of IgA type
       anti-HIV antibodies, especially in infants born to HIV-infected mothers.
       METHODS: Using anti-human IgA monoclonal antibody (22C) and purified p24
       antigen, ELISA system was developed. Sera and saliva were obtained from
       71 HIV-infected individuals of AC, ARC, and AIDS. Anti-p24 antibodies in
       sera of 4 families with HIV infection were also studied. RESULTS: 1. The
       titer of anti-p24 IgA as well as IgG antibodies decreases with
       progression of the disease. 2. In saliva samples the detection of
       anti-p24 IgA antibody appeared to be more sensitive than that of
       anti-p24 IgG antibody. 3. Anti-p24 IgA antibodies in sera of infants
       with HIV infection were significantly high, comparing to that of normal
       infants. DISCUSSION AND CONCLUSIONS: Detection of HIV-specific IgA
       antibodies has diagnostic value of HIV infection especially in infants
       born to HIV-infected mother.
 DE    Comparative Study  Evaluation Studies  Female  Human  HIV
       Antibodies/*ANALYSIS/BLOOD/IMMUNOLOGY  HIV Core Protein p24/IMMUNOLOGY
       HIV Infections/CONGENITAL/*DIAGNOSIS  HIV-1/*IMMUNOLOGY
       IgA/*ANALYSIS/BLOOD/IMMUNOLOGY  IgG/ANALYSIS  Infant, Newborn  Pregnancy
       Pregnancy Complications, Infectious  Saliva/*IMMUNOLOGY  Salivary
       Proteins/*ANALYSIS  Sensitivity and Specificity  MEETING ABSTRACT

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