Document 2790
 DOCN  M94A2790
 TI    Effect of long term therapy with glycyrrhizin for HIV infection in a
       hemophilia patient.
 DT    9412
 AU    Imaizumi M; Goto Y; Tada K; Mori K; Dept. of Pediatrics, Tohoku Univ.
       School of Medicine, Sendai,; Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):224 (abstract no. PB0326). Unique
       Identifier : AIDSLINE ICA10/94369785
 AB    Glycyrrhizin (GL), an aqueous extract of licorice root in Chinese
       medicine, has as an antiinflammatory as well as anti-viral effects.
       Recently, based on in vitro studies proving anti-HIV effects of GL, a
       clinical trial of GL for HIV infection has been under investigation. In
       this report, we present a patient who has been treated only with a
       long-term GL therapy. Case presentation. The patient was a 5-year-boy
       when he was diagnosed as Hemophilia A. At 9 years of age, he was
       presented with suppurative skin lesions and lymphadenopathy, and
       diagnosed as HIV infection in asymptomatic carrier (AC) stage based on
       diminished reaction in skin test, decreased response of his lymphocytes
       to T-cell mitogens, low CD4+ T-cell counts in peripheral blood
       (651/microliters) with a decreased ratio of CD4/CD8 (0.37), and
       positivity for antibody against HIV. Initially, GL was administrated
       intravenously with GL solution (2 mg/ml) dissolved in saline together
       with glycine and cysteine in a dose 5 ml/kg/day for 3 weeks, and then
       doses of infusion were gradually reduced over 2 years and 2 months.
       Then, he has been treated with oral administration of GL up to now.
       Results and Conclusion CD4+ T-cell counts increased more than
       1000/microliters by several weeks and CD4/CD8 ratio improved to 1.0 by 3
       months after an initiation of GL administration. Mild lymphadenopathy
       disappeared by 3 years of GL administration, and he has been staying in
       AC stage for 7 years and 8 months. The examinations in recent two years
       revealed alterations of CD4+ T-cell counts and CD4/CD8 ratios within 400
       to 1000/microliters and 0.55 to 0.71, respectively, in a slowly
       declining course. The clinical course of this patient suggests that GL
       therapy for a long term may be useful for decelerating disease
       progression if started with high doses in an early stage of HIV
       infection.
 DE    Adjuvants, Immunologic/*THERAPEUTIC USE  Case Report  Child, Preschool
       Glycyrrhetinic Acid/*ANALOGS & DERIVATIVES/THERAPEUTIC USE
       Hemophilia/COMPLICATIONS  Human  HIV Infections/COMPLICATIONS/*THERAPY
       Leukocyte Count  Male  T4 Lymphocytes  MEETING ABSTRACT

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