Document 2803
 DOCN  M94A2803
 TI    Blocking effects of FK506 for apoptotic cell death induced by HIV-gp120.
 DT    9412
 AU    Sekigawa I
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):221 (abstract no. PB0315). Unique
       Identifier : AIDSLINE ICA10/94369772
 AB    OBJECTIVE: We investigated about blocking effects of FK506 for apoptotic
       cell death induced by HIV-gp120. METHODS: Normal human PBL were cultured
       with gp120, at 12 hours intervals, anti-TCR antibodies were added to the
       culture. Cell viabilities were measured by trypan blue uptakes. To
       investigate blocking effects of FK506 for cell death, FK506 added to
       cultures. RESULTS: Cell death was induced by the presence of gp120
       followed by signaling through the TCR. FK506 could inhibit this
       apoptotic cell death in a dose dependent manner of FK506. DISCUSSION:
       Apoptotic cell death is known to play an important role for the decline
       of CD4+ cell death in HIV infection. FK506 could inhibit gp120 induced
       cell death. This suggest that FK506 has potential as one of the anti-HIV
       agent for delay of AIDS expression.
 DE    Apoptosis/*DRUG EFFECTS  Cells, Cultured  Depression, Chemical
       FK-506/*PHARMACOLOGY  Human  HIV Envelope Protein gp120/*PHARMACOLOGY
       *HIV-1  Receptors, Antigen, T-Cell/IMMUNOLOGY  T-Lymphocytes/*DRUG
       EFFECTS/MICROBIOLOGY  MEETING ABSTRACT

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