Document 2883
 DOCN  M94A2883
 TI    Anti-HIV flavonoids from Morus alba L.
 DT    9412
 AU    Luo SD; Nemec J; Ning BM; Li QX; Kunming Institute of Botany, China.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):203 (abstract no. PB0240). Unique
       Identifier : AIDSLINE ICA10/94369692
 AB    San Baipi. root of Morus alba L. (Moraceae) is a traditional Chinese
       medicine for cough, asthma and other diseases. The alcohol extract of
       San Baipi displayed activity against HIV in vitro. Solvent partition,
       fractionation on CC and preparing TLC provided three anti-HIV
       flavonoids: morusin, kuwanon H and morusin-4'-glucoside. The results of
       anti-HIV test of morusin, kuwanon H and their derivatives indicated that
       the site between 2-free hydroxy and 3-y,y-dimethylallylic group of these
       flavonoids was sensitive to photo-oxidation, and contributed to anti-HIV
       activity. This paper is the first report on preparing, physical data,
       anti-HIV activity and cytotoxicity of morusin-2'-glucoside,
       morusin-4'-glucoside, kuwanon H-6'-aoctare kuwanon H-7-aoetate and
       triacetate mulberrofuran D.
 DE    Alcohol, Ethyl  Antiviral Agents/CHEMISTRY/ISOLATION &
       PURIF/*PHARMACOLOGY  Bioflavonoids/CHEMISTRY/ISOLATION &
       PURIF/*PHARMACOLOGY  Cells, Cultured/DRUG EFFECTS  Drugs, Chinese
       Herbal/CHEMISTRY/ISOLATION & PURIF/*PHARMACOLOGY
       Flavones/CHEMISTRY/ISOLATION & PURIF/PHARMACOLOGY  Human  HIV/*DRUG
       EFFECTS  Photochemistry  Plant Extracts  MEETING ABSTRACT

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