Document 2895
 DOCN  M94A2895
 TI    Clinical evaluation of a HIV+ patient with Guillain-Barre syndrome
       (GBS).
 DT    9412
 AU    Watanabe R; Iino M; Tachikawa H; Honda M; Sagara H; Yokohama City
       Hospital, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):200 (abstract no. PB0227). Unique
       Identifier : AIDSLINE ICA10/94369680
 AB    OBJECTIVE: a) To evaluate the clinical course and treatment of the first
       Japanese HIV+ patient with GBS. b) To investigate the immunological
       background of the patient. METHODS: Regular neurological examination was
       carried out to assess both the clinical course and the effect of the
       treatment, especially of AZT and steroid. Antibodies to the peripheral
       nerve, Campylobacter Jejuni and a series of viruses were investigated.
       RESULTS: The weakness, which was asymmetric including unilateral tongue
       atrophy, progressed for more than one month and began to recede after 5
       months. The clinical course was not influenced by treatment with steroid
       or AZT. The antibody to Campylobacter Jejuni was negative. Pleocytosis
       in CSF was observed, but it later reverted to normal. CONCLUSION: The
       clinical picture of GBS with HIV infection was different from typical
       GBS in terms of time course, weakness pattern and CSF findings.
       Progression of the weakness was more protracted, but recovery was
       observed even 8 months after onset. No definite neuroimmunological
       background was disclosed.
 DE    Case Report  Cerebrospinal Fluid/CYTOLOGY  Human  HIV
       Infections/*COMPLICATIONS/DRUG THERAPY/IMMUNOLOGY
       Polyradiculoneuritis/CEREBROSPINAL FLUID/*COMPLICATIONS/  IMMUNOLOGY
       Steroids/THERAPEUTIC USE  Zidovudine/THERAPEUTIC USE  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).