Document 2897
 DOCN  M94A2897
 TI    Pediatric AIDS in Sao Paulo-Brazil = 8 years later.
 DT    9412
 AU    Queiroz W; Della Negra M; Yu CL; Paste AA; Soraggi Neto C; Silva LM;
       Vazquez LM; Inst. Infectol. Emillio Ribas, Sao Paulo, SP, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):20 (abstract no. 053B). Unique
       Identifier : AIDSLINE ICA10/94369678
 AB    OBJECTIVES: To show the clinical and epidemiological features of HIV
       infected children followed in a specialized service in Sao Paulo,
       Brazil. METHODS: Since 1986 419 children up to 13 years of age were
       followed in our center, by the same medical team. We analyzed
       retrospectively their risk factors, maternal risk factors (in case of
       vertical transmission), follow up abandonment rate, death (age and causa
       mortis) and present age distribution. Necropsy studies are performed
       regularly. RESULTS: In our center 13.1% of the children are current
       classified as P-o, 4.5% as P-1, 60.0% as P-2 and 22.4% are
       seroreverters. The mean age of serorevertion was 9 months. Of all the
       HIV infected children, 81.0% were infected by Vertical Transmission,
       17.1% by blood or derivatives transfusion, 0.7% by high risk sexual
       activity and the risk factor remains unknown in 1.2%. Among the HIV
       vertically infected children the maternal risk factor was high risk
       sexual activity in 17.5% of the cases, use of IV drugs in 16.4%,
       association of sex and drugs in 17.8%, blood transfusion in 2.2% and
       remains un-known in 46.1%. The follow up abandonment rate is 15% and 49%
       of our patients have died. Among the vertically infected group the mean
       age of death was 19.8 mo. and 52.5% of them died during the first year
       of life. Septicemia and bacterial pneumonia were the most frequent causa
       mortis. Curiously Pneumocystis carinii pneumonia (PCP) was infrequent as
       a cause of death in our means. Currently 14.4% of the vertically
       infected children in follow up are less than 2 years old, 60.8% are
       between 2 and 5 years and 24.8% are older than 5. COMMENTS: Perinatal
       transmission is the most important risk factor in our sample. The high
       percentage of unknown maternal risk factor is due to the large number of
       institutionalized children, abandoned soon after birth. The incidence of
       death in the first year of life is high, but seldom due to PCP. The
       vertically infected children who survive longer than 2 years show the
       possibility of survival longer than 5 years. This may be due to the
       different HIV versus host interactions, viral load and/or timing of
       infection.
 DE    Acquired Immunodeficiency Syndrome/*MORTALITY/TRANSMISSION  Adolescence
       AIDS-Related Opportunistic Infections/MORTALITY  Bacterial
       Infections/COMPLICATIONS  Cause of Death  Child  Child, Abandoned
       Child, Preschool  Human  HIV Seropositivity  Infant
       Pneumonia/COMPLICATIONS  Retrospective Studies  Risk Factors
       Septicemia/COMPLICATIONS  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).