Document 2900
 DOCN  M94A2900
 TI    Outbreak of CNS toxoplasmosis due to AIDS in Bombay.
 DT    9412
 AU    Lanjewar DN; Dept. of Pathology, Grant Medical College, Bombay, India.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):199 (abstract no. PB0223). Unique
       Identifier : AIDSLINE ICA10/94369675
 AB    OBJECTIVE: To determine the incidence of CNS opportunistic infection
       among patients with AIDS. METHODS: Forty cases of AIDS were included in
       autopsy study. Examination of brain was carried out by H & E stain.
       Special stains were carried out for tubercle bacilli, fungal infection
       and myelin fibres. RESULTS: Morphologic lesions in brain were identified
       in 17 of 40 cases (42.5%). Acute encephalitis caused by T.gondii was
       diagnosed in 10 cases (25%). These lesions comprised of ischemic
       necrosis, vasculitis, vascular thrombi, hypertrophic occlusive arteritis
       and presence of free and cyst form of T. gondii in brain. The imprint
       smear cytology of necrotic lesions in brain also showed free forms of T.
       gondii. Other opportunistic infections were cryptococcosis (3 cases),
       candidiasis (1 case) TB meningitis and tuberculoma (1 case each) and
       pyogenic meningitis (1 case). CONCLUSION: CNS toxoplasmosis is the
       commonest opportunistic infection in AIDS patients of Bombay. All cases
       of CNS toxoplasmosis were not suspected antemortem which emphasize the
       necessity of including toxoplasmosis in differential diagnosis of
       encephalitis in patients with AIDS.
 DE    AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/MICROBIOLOGY/
       PARASITOLOGY  Candidiasis/EPIDEMIOLOGY  *Disease Outbreaks
       Encephalitis/*EPIDEMIOLOGY/MICROBIOLOGY/PARASITOLOGY  Human
       India/EPIDEMIOLOGY  Meningitis, Cryptococcal/EPIDEMIOLOGY
       Toxoplasmosis, Cerebral/*EPIDEMIOLOGY  Tuberculoma/EPIDEMIOLOGY
       Tuberculosis, Meningeal/EPIDEMIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).