Document 2902
 DOCN  M94A2902
 TI    HIV associated dementia: frequency and differentiating factors compared
       to other neurological complications of HIV infection.
 DT    9412
 AU    Sanchez-Portocarrero J; Jimenez-Escrig A; Ayuso J; Perez-Cecilia E; Roca
       V; Barquero M; Varela de Seijas E; Hospital Clinico, Madrid, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):199 (abstract no. PB0224). Unique
       Identifier : AIDSLINE ICA10/94369673
 AB    OBJECTIVES: Define the frequency of appearance of HIV associated
       dementia (HAD) and establish the differentiating factors which may exist
       when it is compared to other HIV associated neurological disorders
       (HAND). METHOD: During a period of four years (1989-1992) we studied
       prospectively the patients presenting HAND in our hospital. RESULTS: Out
       of a total of 142, 23 patients (16.2%) were diagnosed as having HAD
       according to WHO criteria; this condition is the second most common
       HAND, after cerebral toxoplasmosis. No statistically significant
       differences sex, age, risk group, or stage of HIV infection- were
       established between the HAD patients and the other HAND diagnosed in the
       group. Among the HAD patients, levels of hemoglobin, hematocrit and
       total lymphocytes were significantly lower, and the B2M and IgA blood
       levels were higher. CD4-cell count showed no differences between the
       groups. HAD was associated with a CT scan with cerebral atrophy. HAD
       patients had a higher survival rate, with a bad functional situation and
       a lesser frequency of deaths of neurological origin. CONCLUSION: HAD is
       the second most frequent HAND. In relation to other HAND, it has a very
       low mortality of neurological origin, and a very high morbidity.
 DE    Atrophy  AIDS Dementia Complex/BLOOD/DIAGNOSIS/*EPIDEMIOLOGY
       Brain/PATHOLOGY  Comparative Study  Diagnosis, Differential  Hematocrit
       Hemoglobins/ANALYSIS  Human  HIV Infections/*COMPLICATIONS/MORTALITY
       Leukocyte Count  Nervous System
       Diseases/DIAGNOSIS/*EPIDEMIOLOGY/ETIOLOGY  Risk Factors  Survival
       Analysis  Toxoplasmosis, Cerebral/DIAGNOSIS/EPIDEMIOLOGY  MEETING
       ABSTRACT

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