Document 2904
 DOCN  M94A2904
 TI    Predictive factors of sequelae in AIDS patients with brain
       toxoplasmosis.
 DT    9412
 AU    Perez-Cecilia E; Sanchez J; Jimenez-Escrig A; Roca V; Romero J; Palau E;
       Picazo J; Hospital Clinico, Madrid, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):198 (abstract no. PB0222). Unique
       Identifier : AIDSLINE ICA10/94369671
 AB    OBJECTIVE: To determine predictive factors of sequelae, in AIDS patients
       (pts) with brain toxoplasmosis (BT), properly treated. METHODS: 33 pts
       diagnosed of BT were included. Diagnosis was based in clinical and
       imaging criteria and a positive response to antitoxoplasma therapy
       (91%), or a pathological proven disease (9%). No pt was in coma at the
       time of diagnosis. Variables evaluated were age, sex, risk factors for
       HIV infection, clinical, biochemical and image variables, immunological
       status, and evolution of the disease. RESULTS: 3(9%) pts died in the
       initial 30-days of disease. From the 30 survivals, 7 (23%) developed
       sequelae: 3 cognitive impairment, 2 ataxia and 2 dystonia. CD4-cell
       count was not related with sequelae. Variables significantly related
       with the presence of sequelae were: TABULAR DATA, SEE ABSTRACT VOLUME.
       CONCLUSIONS: The factors predictive of sequelae in AIDS pts with BT in
       our sample were: longer evolution of disease and presence of
       nonenhancing lesions and posterior fossa lesions. In these patients with
       ominous factors, new treatment of BT should be assayed.
 DE    Ataxia/EPIDEMIOLOGY/*ETIOLOGY  AIDS-Related Opportunistic
       Infections/BLOOD/*COMPLICATIONS/  RADIOGRAPHY  Cognition
       Disorders/EPIDEMIOLOGY/*ETIOLOGY  Cranial Fossa, Posterior
       Dystonia/EPIDEMIOLOGY/*ETIOLOGY  Human  Leukocyte Count  Risk Factors
       Time Factors  Tomography, X-Ray Computed  Toxoplasmosis,
       Cerebral/BLOOD/*COMPLICATIONS/RADIOGRAPHY  T4 Lymphocytes  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).