Document 2913
 DOCN  M94A2913
 TI    Prognostic value of conventional EEG-recordings in evaluating
       HIV-encephalopathy.
 DT    9412
 AU    Arendt G; Bohn J; Schroerschwarz T; von Giesen HJ; Roick H; Jablonowski
       H; Department of Neurology, Univ. Dusseldorf, FRG.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):196 (abstract no. PB0211). Unique
       Identifier : AIDSLINE ICA10/94369662
 AB    OBJECTIVE: HIV-1-related dementia is said to be subcortical and
       cortical. Whereas the subcortical form presents early in the course of
       the disease with cognitive and motor signs, the cortical deficits are
       not very well studied to date. METHODS: 109 neurologically asymptomatic
       (no clinical, no markedly subclinical motor or cognitive deficits)
       HIV-positive homosexuals (CDC II n = 29; CDC III n = 17; CDC IVA n = 4;
       CDC IV C1 n = 16; CDC IV C2 n = 32; CDC IV D n = 11) underwent
       conventional EEG-recordings according to the 10/20 system every six
       months over an 18 months period. Alpha, beta, theta and delta
       frequencies were spectralanalyzed. Results were correlated to the
       clinical course and to CT and MRI scans. RESULTS: The most significant
       EEG findings were a slowing of the alpha rhythm (< 9Hz) and a
       pathological theta-index (> 10%) presenting in a higher percentage of
       AIDS (19.1-54.0%) than non-AIDS (15.2-45.7%) patients. AIDS patients
       with abnormal EEG-recordings revealed cortical atrophy in neuroimaging
       whereas non-AIDS patients had normal scans. Non-AIDS patients revealed
       no significant deterioration over time, but AIDS-patients showed a
       continuous slowing of the alpha rhythm during the observation period.
       Theta index abnormalities remained unchanged. In contrast to non-AIDS
       individuals, 50% of the AIDS patients with initial EEG abnormalities
       revealed signs of cortical dementia within the observation period,
       nearly all of those showed also subcortical dementive signs. CONCLUSION:
       EEG abnormalities--especially slowing of the alpha-rhythm--are of some
       prognostic value for the development of cortical HIV-1-related
       encephalopathy in AIDS, but not in non-AIDS patients.
 DE    Atrophy  AIDS Dementia Complex/EPIDEMIOLOGY/*PHYSIOPATHOLOGY  Cerebral
       Cortex/PATHOLOGY  *Electroencephalography  Human  Prognosis  MEETING
       ABSTRACT

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