Document 2914
 DOCN  M94A2914
 TI    Intrathecal synthesis of anti gp120 V3 loop antibodies in HIV-infection.
 DT    9412
 AU    Mata S; Lolli F; Pinto F; Colao MG; DeMajo E; Mecocci L; Brizzi M; Blanc
       PL; Paci P; Mazzotta F; Department of Neurological Sciences, University
       of Florence,; Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):196 (abstract no. PB0213). Unique
       Identifier : AIDSLINE ICA10/94369661
 AB    OBJECTIVE: The detection of CSF antibody against the V3 loop of HIVMN by
       peptide ELISA has been recently reported in a high percentage of
       patients (LUCEY DR et al., J. AIDS 1993, 6:994-1001). We re-evaluated
       the occurence of intrathecal synthesis (ITS) of antibodies to the V3
       loop of HIVMN. METHODS: We measured the antibodies to the HIV gp120 V3
       loop (strain MN) in the cerebrospinal fluid and serum of 47 HIV infected
       patients by peptide-ELISA. RESULTS: Antibodies to V3 were detected in
       the serum of 94% and in the CSF of 78% of the patients. ITS of the
       antibodies took place in only 30% of the patients and in low levels
       (mean ratio of serum/CSF titers equal to 215). All patients presented
       intrathecal synthesis of antibodies to gp 120 by Western blot.
       CONCLUSION: Despite the ITS of antibodies to gp 120 in HIV infection,
       the antibody response to the V3 loop is of much lower level and thus
       constititute a basis for the defective immunoregulation of the virus in
       the nervous system.
 DE    Cerebrospinal Fluid Proteins/*IMMUNOLOGY  Comparative Study  HIV
       Antibodies/BIOSYNTHESIS/BLOOD/*CEREBROSPINAL FLUID  HIV Envelope Protein
       gp120/*IMMUNOLOGY  HIV Infections/BLOOD/*CEREBROSPINAL FLUID/IMMUNOLOGY
       HIV-1/*IMMUNOLOGY  Peptide Fragments/*IMMUNOLOGY  MEETING ABSTRACT

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