Document 2915
 DOCN  M94A2915
 TI    HIV and the brain: P300 changes do not reflect general subcortical
       damage.
 DT    9412
 AU    Katner HP; Moore NC; Tucker KA; Smith MU; Coburn KL; Department of
       Medicine, Mercer University School of Medicine,; Macon, GA 31208.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):196 (abstract no. PB0214). Unique
       Identifier : AIDSLINE ICA10/94369660
 AB    OBJECTIVES: Evidence of HIV encephalopathy can be found shortly after
       seroconversion as a delayed and attenuated P300 auditory event related
       potential (ERP) component. P300 changes occur before dementia, while the
       EEG is normal, and increase with successive infection stages (Coburn et
       al. NeuroReport 3(6): 539-541, 1992). This could reflect either a
       general subcortical deterioration or a more specific involvement of the
       hippocampal pathways mediating the P300 and other cognitive functions. A
       general subcortical deterioration should involve the widely distributed
       subcortical visual pathways, producing visual ERP abnormalities.
       METHODS: Pattern reversal ERP's (N75, P100 & asymptomatic HIV+ (n = 10),
       ARC (n = 9), and AIDS (n = 9) subjects. RESULTS: Although these HIV
       patients had highly significant P300 changes, visual ERP's did not
       differ between any patient group and healthy controls, or between
       patient groups representing increasing infection stages. DISCUSSIONS &
       CONCLUSIONS: The finding of normal visual ERP's with progressive P300
       changes suggests that the earliest subcortical involvement is of the
       hippocampal circuitry rather than being diffuse.
 DE    *Evoked Potentials, Auditory  Evoked Potentials, Visual
       Hippocampus/*PHYSIOPATHOLOGY  Human  HIV Infections/*PHYSIOPATHOLOGY
       MEETING ABSTRACT

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