Document 2919
 DOCN  M94A2919
 TI    Hypocholesterolemia and psychological distress in HIV-1 disease.
 DT    9412
 AU    Shor-Posner G; Feaster D; Blaney N; Miguez-Burbano M; Goodkin K;
       Elsdorfer C; Baum MK; Department of Epidemiology, University of Miami
       School of; Medicine, FL.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):195 (abstract no. PB0208). Unique
       Identifier : AIDSLINE ICA10/94369656
 AB    OBJECTIVE: Altered serum lipid concentrations, (hypertriglyceridemia,
       hypocholesterolemia) which have been documented in HIV-1 disease, have
       been associated with behavioral abnormalities. The present study
       determined the relationship between lipid status and psychosocial
       behavior in 118 HIV seropositive (CDC Stages II, III n = 96; CDC Stage
       IV 2A n = 22) and 52 seronegative homosexual men. METHODS: Extracted
       serum was saponified, followed by oxidation condensation reactions to
       produce a fluorescing compound for triglyceride analysis. Levels of
       cholesterol were similarly obtained from serum extracts after reaction
       with Lieberman-Buchard color reagent, and read as absorbance at 630 nm
       (Technicon Auto Analyzer II). Psychological distress was measured with
       the Profile of Mood States. RESULTS: Hypocholesterolemia (< 150 mg/dl)
       was observed in 41% of the infected men and 24% of the controls.
       Analysis of variance, controlling for HIV-1 status, indicated
       significantly higher distress in subjects with low cholesterol as
       compared to subjects with serum cholesterol levels in the normal range
       (p < 0.026). In addition, a significant interaction between stress and
       hypocholesterolemia was observed in a model of psychological distress,
       which included stress, coping style and social support (p < .043).
       Hypertriglyceridemia (> 160 mg/dl), occurred in 11% of the seropositives
       and 19% of the seronegatives, but, was not associated with elevated
       distress. DISCUSSION AND CONCLUSIONS: The significant association
       between hypocholesterolemia and psychological distress supports the
       suggestion that altered lipid status may be linked to disturbances in
       behavior.
 DE    Adaptation, Psychological  Affect  Affective Disorders/BLOOD/*ETIOLOGY
       Cholesterol/BLOOD/*DEFICIENCY  Human  Hypertriglyceridemia/PSYCHOLOGY
       HIV Infections/*BLOOD/PSYCHOLOGY  *HIV-1  Male  Social Support  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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