Document 2920
 DOCN  M94A2920
 TI    Stereotactic brain biopsy in AIDS patients.
 DT    9412
 AU    Valadas E; Melo AZ; Ferreira G; Quaresma MJ; Infectious Diseases
       Department, Hospital de Santa Maria, Lisbon,; Portugal.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):194 (abstract no. PB0206). Unique
       Identifier : AIDSLINE ICA10/94369655
 AB    One of the most important problems in HIV seropositive patients is the
       differential diagnosis of possible treatable cerebral mass lesions
       visualized in CT scan or MRI. The need for a rapid diagnosis is
       unquestionable; however, the indications and timing for brain biopsy
       remain controversial. In order to evaluate the efficacy of steroctatic
       brain biopsy in AIDS patients we retrospectively studied 13 HIV-infected
       patients who underwent stereotactic biopsy from July 1991 to January
       1994. These patients presented with a cerebral mass lesion with a
       non-conclusive CT-scan or MRI or a failure of anti-toxoplasma treatment.
       A definitive diagnosis was achieved in 12/13 patients. Histological
       diagnosis of the biopsy specimens showed primary central nervous system
       lymphoma (PCNSL) (7), progressive multifocal leukoencephalopathy (2),
       astrocytoma (1), syphilis (1) and toxoplasmosis (2). One biopsy was
       non-diagnostic. In this group of patients one death occurred due to
       intracerebral haemorrhage. Stereotactic brain biopsy appears to be an
       effective and safe method of establishing a correct diagnosis of
       selected cases of cerebral pathology in HIV seropositive patients.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  AIDS Dementia
       Complex/*PATHOLOGY  AIDS-Related Opportunistic Infections/PATHOLOGY
       Biopsy  Brain/*PATHOLOGY  Brain Neoplasms/PATHOLOGY  Diagnosis,
       Differential  Human  Leukoencephalopathy, Progressive
       Multifocal/PATHOLOGY  Lymphoma, AIDS-Related/PATHOLOGY  Retrospective
       Studies  *Stereotaxic Techniques  MEETING ABSTRACT

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