Document 2924
 DOCN  M94A2924
 TI    Subclinical motor deficits in HIV infection are not influenced by
       intravenous drug abuse.
 DT    9412
 AU    Giesen HJ; Roick H; Hefter H; Jablonowski H; Freund HJ; Arendt G;
       Department of Neurology, University of Dusseldorf, Germany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):193 (abstract no. PB0199). Unique
       Identifier : AIDSLINE ICA10/94369651
 AB    OBJECTIVE: Electrophysiological evaluation of individual motor
       performance is an appropriate means to quantify subclinical motor
       deficits in HIV Infection. These deficits may later on result in the HIV
       associated cognitive/motor complex. We wanted to find out whether motor
       performance is influenced by intravenous drug abuse (IVDA). METHODS:
       Most rapid alternating movements (MRAM) and the rise time of most rapid
       index finger extension movements (CT = contraction time) as described in
       the literature were measured in 114 HIV positive individuals who
       acquired HIV either by IVDA (n = 57) or via sexual transmission (n =
       57). Both groups were matched for age, time since diagnosis, CD 4 cell
       counts and CDC stages (II n = 20, III n = 19, IV n = 18). Results were
       compared to those of n = 98 HIV negative healthy controls. RESULTS: Mean
       values of MRAM and CT as well as the absolute numbers of pathological
       performance were similar without statistically significant differences
       between both groups irrespective of the mode of infection. They were
       significantly slower (MRAM; p < 0.001 dominant hand) or prolonged (CT; p
       < 0.001 dominant hand) than in the controls. DISCUSSION AND CONCLUSIONS:
       Intravenous drug abuse despite its possible influence on the central
       nervous system does not interfere with the HIV-induced changes of motor
       performance.
 DE    AIDS Dementia Complex/DIAGNOSIS/*PHYSIOPATHOLOGY  Human
       Laterality/PHYSIOLOGY  Motor Skills/*PHYSIOLOGY  Muscle
       Contraction/PHYSIOLOGY  *Neurologic Examination  Neuromuscular
       Diseases/DIAGNOSIS/*PHYSIOPATHOLOGY  Reaction Time/PHYSIOLOGY  Reference
       Values  Substance Abuse, Intravenous/COMPLICATIONS/*PHYSIOPATHOLOGY
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).