Document 2925
 DOCN  M94A2925
 TI    Risk of neuropsychological impairment steadily rises from date of
       seroconversion: HNRC experience.
 DT    9412
 AU    Grant I; Heaton RK; Deutsch R; McCutchan JA; Atkinson JH; Chandler J;
       University of California, San Diego, La Jolla.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):193 (abstract no. PB0200). Unique
       Identifier : AIDSLINE ICA10/94369650
 AB    OBJECTIVE: Neuropsychological (NP) impairment is prevalent in persons
       with AIDS, but the natural course of such impairment is poorly
       understood. We explored risk of NP impairment as a function of years
       since seroconversion. METHODS: The 152 non-intravenous drug using HIV+
       men all had documented dates of negative and positive ELISAs from which
       approximate time of seroconversion could be estimated. Comprehensive NP
       testing included the extended Halstead-Reitan battery. Survival analysis
       was used to determine the hazard of NP impairment in relation to years
       from seroconversion. RESULTS: The Kaplan-Meier plot for time to NP
       impairment revealed that at each successive year from seroconversion the
       risk of becoming impairment was increased, rising from 11%, 14%, to 17%
       in the first 3 years, and then to 26% and 41% in years 4 and 5.
       CONCLUSION: The risk of NP impairment rises steadily with length of
       seropositivity. This is true even for a largely medically asymptomatic
       sample. Our findings contrast with data from some other groups who have
       asserted that risk of NP impairment is negligible until patients become
       symptomatic. These data emphasize the importance of comprehensive
       neurobehavioral studies of samples of seropositive individuals in whom
       dates of seroconversion can be estimated reliably.
 DE    Adult  AIDS Dementia Complex/*DIAGNOSIS/EPIDEMIOLOGY  Follow-Up Studies
       Human  HIV Seropositivity/*DIAGNOSIS/EPIDEMIOLOGY  Male
       *Neuropsychological Tests  Proportional Hazards Models  Risk Factors
       Survival Analysis  MEETING ABSTRACT

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