Document 2943
 DOCN  M94A2943
 TI    Combined p24 antigen and anti-p66 as markers of AIDS-free time.
 DT    9412
 AU    Henrard D; Meiszberg T; Wiesner D; Goedert J; Abbott Labs, Abbott Park,
       IL.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):19 (abstract no. 050B). Unique
       Identifier : AIDSLINE ICA10/94369632
 AB    OBJECTIVE: Assess levels of specific HIV-1 antibodies as early predictor
       of AIDS-free time, especially in p24-antigen (Ag) negative subjects.
       METHODS: Two to ten (mean 5.5) annual samples from 30 homosexual men
       with documented seroconversion dates were studied. Seven men developed
       AIDS in 3 years (group I), 11 developed AIDS in 4-6 years (group II) and
       13 did not develop AIDS in 7 years (group III). HIV-1 p24-Ag was
       detected by a monoclonal EIA; levels of antibody to gp120, gp41, p66,
       p31, p24 and p17 were measured by dot-blot EIA. RESULTS: Within 2 years
       of seroconversion, p24 antigen was detected in 7/7 men in group I, 5/11
       men in group II and 3/13 in group III. Anti-p66 levels were stable or
       increasing in 11 (84%) of 13 group III men vs 4 (36%) of 11 group II
       men. Among p24-Ag negative men, those with stable or increasing levels
       of anti-p66 were 18 times more likely to be in group III than in group
       II. Other antibodies did not as clearly discriminate groups II and III
       in p24-Ag negative men. CONCLUSION: For individuals who remain negative
       for p24-Ag during the early years of infection, decreasing anti-p66 may
       indicate a higher risk of AIDS progression within 4-6 years.
 DE    Biological Markers  Human  HIV Antibodies/*ISOLATION & PURIF  HIV Core
       Protein p24/*IMMUNOLOGY  HIV Envelope Protein gp120/IMMUNOLOGY  HIV
       Seropositivity/*IMMUNOLOGY  Immunoenzyme Techniques  Male  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).