Document 2945
 DOCN  M94A2945
 TI    Liver disease in patients with AIDS.
 DT    9412
 AU    Silva MA; Tannuri AA; Lobo AL; Costa RS; Mello CE; Lima MB; Oliveira CA;
       University of Rio de Janeiro, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):189 (abstract no. PB0183). Unique
       Identifier : AIDSLINE ICA10/94369630
 AB    OBJECTIVE: The evaluation of clinical, biochemical, serological and
       morphological data of liver involvement in high risk groups with AIDS
       was the aim of this work. Our purpose was to determine the spectrum of
       liver disease in AIDS and the clinic morphological correlation in order
       to ascertais if any clinical or phatological feature was characteristic
       of AIDS. MATERIAL: We have evaluated 215 patients with AIDS, being 30
       hemophiliacs (19A and 2B) severely affected and 185 homosexual men.
       METHODS: We studied hepatitis B virus (HBV) serum markers by commercial
       RIA kits for the detection of HBsAg, Anti-HBs, Anti-HBc, HBeAg and
       Anti-HBe. Liver function tests including aminotransferases, total
       bilirubin, alkaline fosfatase were performed. Mostly of the liver
       biopsies were obtained percutaneously, but some samples were obtained
       from necropsy material. RESULTS: The great majority of the patients were
       anicteric. More than 80% of them were Anti-HBs and Anti-HBc(+). Serum
       aminotransferases levels were mildly elevated (less than twice the upper
       limit of the normal range) 10 the majority of the patients. Liver
       tuberculosis, chronic active hepatitis, sinusoidal dilatation,
       hiperplasy of Kupffer cells, cirrhosis were the most frequent findings
       in this study. We also found the presence of hepatocellular carcinoma,
       cryptococcosis, histoplasmosis, amebiasis and schistosomiasis.
       CONCLUSIONS: a) The clinical and biochemical alterations of the liver in
       AIDS patients were subclinical and not very characteristic; b)
       Morphologicaly there was conspicuous predominance of chronic liver
       disease, opportunistic liver infecciousin special due to Mycobacterium.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DIAGNOSIS/  PATHOLOGY
       AIDS-Related Opportunistic Infections/DIAGNOSIS/PATHOLOGY  Biopsy
       Hemophilia/COMPLICATIONS/PATHOLOGY  Hepatitis
       B/COMPLICATIONS/DIAGNOSIS/PATHOLOGY  Human  Liver/PATHOLOGY  Liver
       Cirrhosis/COMPLICATIONS/DIAGNOSIS/PATHOLOGY  Liver
       Diseases/*COMPLICATIONS/DIAGNOSIS/PATHOLOGY  Liver Function Tests
       Substance Abuse, Intravenous/COMPLICATIONS/PATHOLOGY  MEETING ABSTRACT

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