Document 2950
 DOCN  M94A2950
 TI    Clinical significance of hyperamylasemia in HIV patients.
 DT    9412
 AU    Merino E; Reus S; Sanchez J; Trigo C; Boix V; Portilla J; Perez-Mateo M;
       Hospital General Universitario de Alicante, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):188 (abstract no. PB0181). Unique
       Identifier : AIDSLINE ICA10/94369625
 AB    OBJECTIVE: To investigate the origin and clinical significance of
       hyperamylasemia in HIV patients. METHODS: We have studied HIV patients
       with hyperamylasemia (> 220UI/L) admitted at our unit between Oct-92 and
       Jan-94. We investigated history of pancreatitis, alcohol intake and
       previous drugs. Liver and renal function tests, serum lipase (lip),
       pancreatic isoamylasa (iso), immunoreactive trypsin (tryp) levels and
       macroamylasemia (mac) were investigated. Alteration pancreatic
       morphology (alt morp) was evaluated by ultrasound and/or CT abdominal
       scanning. RESULTS: We found 24 patients (7.8%) with hyperamylasemia.
       Mean age 32.6 years, 20 were IVDU. Clinical stage, A3: 1 case, B2: 2,
       B3: 1 and C3: 20 (83%). Six patients had alcohol intake > 40g/day, and
       nobody with previous pancreatitis. Three patients took ddI, 4 inhaled
       monthly pentamidine and 16 TMP-SFX (9 for prophylaxis and 7 for PCN
       treatment). Four cases presented mild increasing in serum creatinine
       (2.3 mg/dl) and 60% had liver enzymes elevated. We made two groups,
       those with at least another pancreatic enzyme increased (group I), and
       those with isolated hyperamylasemia (group II). We didn't find relation
       with any treatment or opportunistic infection. TABULAR DATA, SEE
       ABSTRACT VOLUME. CONCLUSIONS: 1) Asymptomatic hyperamilasemia can appear
       in advanced HIV infection and most of them (87%) are of pancreatic
       origin. 2) Pancreatic morphology is often altered. 3) Subclinic
       pancreatitis in aids is not always drug-related. 4) Hyperamilasemia of
       saliva origin appears in HIV patients with less immunodeficiency.
 DE    Alcoholism/COMPLICATIONS/*ENZYMOLOGY  Amylases/*BLOOD  Diagnostic
       Imaging  Human  HIV Infections/*ENZYMOLOGY  Kidney Function Tests  Liver
       Function Tests  Pancreas/PATHOLOGY  Pancreatic Function Tests
       Pancreatitis/*ENZYMOLOGY/ETIOLOGY  Risk Factors  Substance Abuse,
       Intravenous/COMPLICATIONS/*ENZYMOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).