Document 2956
 DOCN  M94A2956
 TI    Impaired gastric empyting in patients with HIV infection.
 DT    9412
 AU    Piot D; Gathe J Jr; Bernal A; Stool E; Clemmons J; Stenoien R; Goldstein
       J; Park Plaza Hospital, Special Diseases Unit, Houston, Texas.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):186 (abstract no. PB0172). Unique
       Identifier : AIDSLINE ICA10/94369619
 AB    OBJECTIVE: To detail characteristics of HIV infected patients with
       gastric emptying disturbances (GED). METHODS: Retrospective chart review
       of 18 patients followed prospectively by the authors. GED was documented
       by nuclear medicine gastric emptying study. RESULTS: Patient
       characteristics include: Age range 23-63; 16 males, 2 females; T-cell
       profile range 16-466. All patients had one or more documented
       infections: 14 CMV, 1 cryptosporidiosis, 5 mycobacteriosis, 1
       cryptococcus. Symptoms included: nausea (17/18), vomiting (15/18),
       abdominal pain (10/18), diarrhea (8/18), weight loss (8/18), abdominal
       distention (4/18), aspiration pneumonia (1/18). Endoscopy findings
       revealed retained food from meals > 12 hours after ingestion, gastric
       bezoar, and undigested medicines. No specific histopathology was seen.
       Calculated gastric T 1/2 emptying times were abnormal (> 85 minutes) in
       17/20 studies, with a range of 20-300 minutes and a mean of 220 minutes.
       Of the 18 patients, 5 improved, 6 stabilized, 7 died. CONCLUSIONS: 1.
       GED can occur at any time during HIV infection once CD4 counts fall
       below 500. 2. Symptomatic GED was usually discovered with a simultaneous
       systemic infection. 3. Direct complications of GED include: a.
       Aspiration pneumonia, b. Malnutrition, c. Malabsorption of oral
       medications. 4. When GED is documented, important oral medications may
       need to be given parenterally until GED is corrected. 5. Adjuvant
       propulsion agents have been helpful, but the reversibility of GED
       appears to be a reflection of time and the control of infections.
 DE    Adult  Endoscopy, Gastrointestinal  Female  Gastric Emptying/*PHYSIOLOGY
       Human  HIV Infections/*PHYSIOPATHOLOGY  Male  Middle Age  Retrospective
       Studies  Stomach/PHYSIOPATHOLOGY  MEETING ABSTRACT

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