Document 2957
 DOCN  M94A2957
 TI    Human papilloma virus in the esophagus in HIV patients.
 DT    9412
 AU    Bouchaud O; Marche C; Cadiot G; Longuet P; Rene E; Coulaud JP; Bichat
       Claude Bernard Hospital, Paris, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):186 (abstract no. PB0171). Unique
       Identifier : AIDSLINE ICA10/94369618
 AB    OBJECTIVE: Esophagitis (E) in AIDS patients (pts) remain frequently
       without etiology. We would like to show that Human Papillomavirus (HPV)
       may be found in the esophagus and to discuss HPV as a possible agent in
       E. METHODS: We performed a prospective study in pts having had an upper
       endoscopy. Pts were divided in 3 groups: grp 1 = no lesion in the
       esophagus, grp 2 = non ulcerated E, grp 3 = ulcerated E. Standard
       histologic examination, immuno-markers study and in situ hybridization
       (ISH) were performed. In case of positivity of ISH-HPV, confirmation and
       typing by PCR was available. RESULTS: We included 103 pts: 32 in grp 1,
       36 in grp 2, 35 in grp 3. Among them 75 were AIDS, 21 ARC and 4
       asymptomatic. Mean CD4 count was 76/mm3 (4-766). HPV was found in 31% of
       cases and respectively in 34% (grp1), 33% (grp2), 27% (grp3). There was
       no specific risk factor associated with HPV. In 18 cases it was the only
       pathogen found. Confirmation by PCR was always positive. In HPV+ pts,
       mean CD4 count was 113/mm3 (4-766) whereas in HPV- pts mean CD4 count
       was 59/mm3 (4-485); p < 0.05. CONCLUSION: 1) this is the first report of
       HPV in the esophagus in HIV pts. 2) because it is found both in
       esophagus with or without lesion, HPV is probably not an etiologic agent
       in E but could be a co-factor. 3) HPV seems to be associated with an
       immune status less deficient than in pts without HPV.
 DE    AIDS-Related Opportunistic Infections/*PATHOLOGY  Endoscopy,
       Gastrointestinal  Esophagitis/*PATHOLOGY  Esophagus/PATHOLOGY  Human
       *Papillomavirus, Human/ISOLATION & PURIF  Papovaviridae
       Infections/*PATHOLOGY  Polymerase Chain Reaction  Prospective Studies
       MEETING ABSTRACT

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