Document 2968
 DOCN  M94A2968
 TI    Treatment of aphthous oral ulcers with pentoxifylline.
 DT    9412
 AU    Navarro A; Pizarro A; Herranz P; Aguayo M; Leon M; Pujol E; Hospital Jr
       Jimenez, Huelva, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):183 (abstract no. PB0158). Unique
       Identifier : AIDSLINE ICA10/94369607
 AB    OBJECTIVE: Patients infected with human immunodeficiency virus (HIV)
       frecuently have aphtous ulcers (AO) of the oral mucosa. Successful use
       of pentoxifylline has been reported recently in the treatment of AO in
       general population. The purpose of this study was to evaluate the
       efficacy of pentoxifylline in HIV patients with AO. METHODS: Four
       non-selected patients (3 men, 1 woman) with HIV infection and recurrent
       AO (minimum, three episodes in one year) were enrolled in this study.
       Diagnosis of HIV-associated AO should be considered after repeated
       negative cultures and citologies for infectious agents. They started
       medication in a moment of an acute outbreak. Patients received
       pentoxifylline 400 mg/day, three times a day for 4 months. RESULTS:
       Three of our four patients responded to treatment. In this group,
       complete reepithelialization was noted after 1 to 2 weeks and there has
       been no relapse during a follow-up of four months. One patient showed
       resistence of AO to pentoxifylline, so the medication was stopped two
       months after treatment onset. No toxicity or morbidity was noted.
       DISCUSSION AND CONCLUSIONS: Successful use of thalidomide has been
       reported in the treatment of AO in HIV patients, but this therapy has
       considerable potential toxicity, particularly neuropathy. The mode of
       action of thalidomide seems to be related with inhibition of tumor
       necrosis factor (TNF-alpha). Pentoxifylline has recently been
       demonstrated to inhibit TNF-alpha too. Our findings suggest that a
       double-blind controlled trial of pentoxifylline in HIV patients with AO
       should be undertaken.
 DE    AIDS-Related Opportunistic Infections/*DRUG THERAPY  Dose-Response
       Relationship, Drug  Drug Administration Schedule  Female  Follow-Up
       Studies  Human  Male  Pentoxifylline/*ADMINISTRATION & DOSAGE
       Recurrence  Stomatitis, Aphthous/*DRUG THERAPY  MEETING ABSTRACT

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