Document 2972
 DOCN  M94A2972
 TI    Site-specific relationship between oral spirochaetes and periodontal
       disease in human immunodeficiency infection.
 DT    9412
 AU    Wanzala P; Riviere G; Lukehart S; Kreiss J; DeRouen T; Ndinya A; Kenya
       Medical Research Institute.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):182 (abstract no. PB0154). Unique
       Identifier : AIDSLINE ICA10/94369603
 AB    OBJECTIVES: A Study of the distribution of Oral Spirochaetes in HIV
       infected and uninfected individuals and their etiological significance
       in periodontal disease. METHODS: 59 patients were included in the study.
       Loss of attachment was measured at all the sites of teeth present,
       Plaque samples from the 6 most affected sites and two least affected
       sites in the individual. Pathogen-related oral spirochaetes were
       investigated using monoclonal antibodies against pathogen specific
       determinants on 47kDa and 37 kDa molecules. A questionnaire on the
       patient's history and clinical status was also included. Blood was
       collected for analysis for the presence of T. pallidum subsp pallidum.
       RESULTS: A significant relationship was found between the site-specific
       occurrence pathogen-related oral spirochaetes and sites with at least 4
       mm loss of attachment (p < 0.01), with an odds ratio of 4.39 (95% CI =
       (1.5-12.9)), and after adjusting for HIV infection the odds ratio was
       7.6 (95% CI = (0.9-16.8)). CONCLUSION: The study provides a new
       perspective into the etiological mechanisms of periodontal disease
       especially in the HIV infected.
 DE    AIDS-Related Opportunistic Infections/*MICROBIOLOGY  Dental
       Plaque/MICROBIOLOGY  Human  Periodontal Index
       Periodontitis/*MICROBIOLOGY  Spirochaeta/ISOLATION & PURIF
       Spirochaetales Infections/*MICROBIOLOGY  MEETING ABSTRACT

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       protected by Copyright Law (Title 17, U.S.Code).