Document 2973
 DOCN  M94A2973
 TI    Oral hairy leukoplakia (OHL): topical use of trichloroacetic and
       glycolic acids--results.
 DT    9412
 AU    Nishio CE; Petri V; Narahashi E; Department of Dermatology, Escola
       Paulista de Medicina, SP,; Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):182 (abstract no. PB0153). Unique
       Identifier : AIDSLINE ICA10/94369602
 AB    OBJECTIVE: to investigate perspectives of control of oral hairy
       leukoplakia (OHL) of HIV-seropositive patients. METHODS: 10
       HIV-seropositive individuals were submitted to trichloroacetic acid
       (TCA) 40% and 10 other (HIV-seropositive) to glycolic acid (GA) 30%,
       topically. RESULTS: all patients reported good results if using TCA or
       GA regularly (2 to 3 times a week for TCA, 1 to 2 times a day for GA).
       All patients referred recurrence of OHL if treatment is interrupted. No
       significant discomfort was related in both cases. TCA seemed to be more
       quickly effective (24-48 hours after topical use), in spite of its
       relatively non-aesthetics aspect in the first 12-24 hours after
       administration (see figure); GA was apparently effective after 10 to 21
       days of regular treatment. CONCLUSIONS: TCA and/or GA, both effective
       products used against some cutaneous viral and non-viral diseases
       (papillomavirus, molluscum contagiosum and queratotic disorders of the
       skin), can be used easily, without significant discomfort and relatively
       good results, during the time of persistence of OHL (see figures).
 DE    Administration, Topical  Comparative Study  Drug Administration Schedule
       Glycolates/*ADMINISTRATION & DOSAGE  Human  HIV Seropositivity/*DRUG
       THERAPY  Leukoplakia, Hairy/*DRUG THERAPY  Recurrence  Treatment Outcome
       Trichloroacetic Acid/*ADMINISTRATION & DOSAGE  MEETING ABSTRACT

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