Document 2975
 DOCN  M94A2975
 TI    CD4+ and CD8+ lymphocytes in gingival tissue from HIV-infected persons.
 DT    9412
 AU    Odden K; Schenck K; Hurlen B; Dental Faculty, University of Oslo,
       Norway.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):182 (abstract no. PB0156). Unique
       Identifier : AIDSLINE ICA10/94369600
 AB    OBJECTIVE: The aim of the present study was to examine whether the
       general HIV-related decline in CD4+ T-lymphocytes and CD4+/CD8+ ratio is
       reflected in gingival tissues, and thus can constitute a possible
       explanation of HIV-infected persons susceptibility to periodontal
       diseases. METHODS: Frozen sections of gingival biopsies taken from 31
       HIV-infected persons (11 with gingivitis and 20 with periodontitis) and
       14 HIV seronegative persons with periodontitis were stained with
       monoclonal antibodies against CD4 and CD8. Positive cells were counted
       and CD4/CD8 ratio compared with the same ratio in peripheral blood.
       RESULTS: In the HIV-infected persons consistently fewer CD4+ than CD8+
       cells were found in the gingival tissues, whereas in the HIV
       seronegative group fewer CD8+ than CD4+ lymphocytes were common. The
       CD4/CD8 ratio was significantly higher in the gingiva than in peripheral
       blood in the HIV-infected group, but the ratio was the same in the two
       localizations in the HIV seronegative group. CONCLUSIONS: HIV-related
       immunodeficiency is reflected in gingiva as a low CD4/CD8 ratio. This
       might lead to raised susceptibility to periodontal diseases. The higher
       CD4/CD8 ratio in the gingiva compared to peripheral blood means that
       CD4+ cells are attracted to inflamed areas also when these cells are
       few.
 DE    AIDS-Related Opportunistic Infections/*IMMUNOLOGY/PATHOLOGY  Biopsy
       *CD4-CD8 Ratio  Gingiva/IMMUNOLOGY/PATHOLOGY
       Gingivitis/*IMMUNOLOGY/PATHOLOGY  Human  Leukocyte Count
       Periodontitis/*IMMUNOLOGY/PATHOLOGY  T4 Lymphocytes/*IMMUNOLOGY  MEETING
       ABSTRACT

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