Document 2992
 DOCN  M94A2992
 TI    Signet cell carcinoma of the stomach in a patient with AIDS: a case
       report.
 DT    9412
 AU    Uchida T; Takamatsu Red Cross Hospital, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):178 (abstract no. PB0139). Unique
       Identifier : AIDSLINE ICA10/94369583
 AB    OBJECTIVE: A case of signet cell cancer associated with AIDS is
       presented. CASE HISTORY: A 50-year-old Japanese man with hemophilia A
       had required multiple injections of factor VIII concentrate since 1973.
       He developed dysphagia, heartburn and hiccups on July 1987. He lost 10kg
       in weight during 2 months. No lymph-node swelling or Kaposi's sarcoma
       was found. An upper GI series showed an obstruction in the esophageal
       region. The biopsy showed signet cell carcinoma. In addition to gastric
       cancer, an esophageal candidiasis was also observed in an endoscopic
       examination. HIV antibody was positive in gp160, 120, 41, p55, 32, 24,
       18 by WB. The HIV antigen was negative. Twenty days after his admission,
       febrile condition reached a continuous 40C. Cultures of blood grew
       candida species. CD4 lymphocytes decreased by less than 400/ul since the
       end of October. His massive hemorrhage from the gastric cancer continued
       and he died on November 24, 1987. DISCUSSION AND CONCLUSIONS: Signet
       cell carcinoma is not one of the cancers typically seen in AIDS. It is
       possible that the patient had a coincidental carcinoma along with AIDS.
       It is suggested, however, that the HIV infection had a role in causing
       the signet cell carcinoma, giving rise to its classification as an
       opportunistic tumor.
 DE    Acquired Immunodeficiency Syndrome/*DIAGNOSIS/TRANSMISSION  AIDS
       Serodiagnosis  AIDS-Related Opportunistic Infections/DIAGNOSIS
       Candidiasis/DIAGNOSIS  Carcinoma, Signet Ring Cell/DIAGNOSIS  Case
       Report  Factor VIII/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS
       Hemophilia/THERAPY  Human  HIV Antibodies/ANALYSIS  Male  Middle Age
       Stomach Neoplasms/*DIAGNOSIS  MEETING ABSTRACT

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