Document 2995
 DOCN  M94A2995
 TI    AIDS-related primary central system lymphoma treated with radiotherapy:
       over a decade of clinical experience at UCSF.
 DT    9412
 AU    Ling C; Coleman L; Roach M; Wara W
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):178 (abstract no. PB0137). Unique
       Identifier : AIDSLINE ICA10/94369580
 AB    OBJECTIVES: To determine the length of survival of patients with
       AIDS-related primary central nervous system lymphoma (PCNSL) after
       treatment with radiotherapy, and to determine whether length of survival
       (LOS) correlated with dose of radiotherapy, pre-treatment Karnofsky
       performance status (KPS), risk factors, age, CD4 counts, length of time
       since seroconversion, clinical response, radiological findings,
       pathology, chemotherapy or AIDS medications, clinical symptomatology or
       presence of other AIDS-related illnesses. METHODS: Using our
       diagnosis-based computer retrieval system all patients treated with
       radiotherapy for AIDS-related PCNSL between January, 1982 and January,
       1994 were identified and their medical records were reviewed. Population
       characteristics, risk factors and LOS were analyzed. Statistical
       methodology included the Cox proportional hazards model and Kaplan-Meler
       survival curves. RESULTS: 57 patients were identified as having
       AIDS-related PCNSL. Although there was an eightfold increase of cases in
       the last six years of this study as compared with the first six years,
       this now appears to be levelling off. The average KPS score was 50. The
       median LOS was 3 months and did not appear to correlate significantly
       with any of the above factors except for KPS score. CONCLUSIONS: The
       outcome of AIDS-related PCNSL continues to be dismal despite improved
       general medical and supportive care.
 DE    Brain Neoplasms/MORTALITY/*RADIOTHERAPY  *Cranial Irradiation  Follow-Up
       Studies  Human  Karnofsky Performance Status  Lymphoma,
       AIDS-Related/MORTALITY/*RADIOTHERAPY  Proportional Hazards Models
       Radiotherapy Dosage  Survival Rate  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).