Document 2997
 DOCN  M94A2997
 TI    Proton magnetic resonance in vivo spectroscopic energy metabolite
       screening in AIDS.
 DT    9412
 AU    Sharma R; Sharma A; Agrawala A; Rehani MM; I.I.T. Delhi, India.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):177 (abstract no. PB0134). Unique
       Identifier : AIDSLINE ICA10/94369578
 AB    An attempt was made to monitor the effect of cisplatin i.v. therapy in
       AIDS related lymphoma. Before therapy and after treatment, NMR spectra
       were compared. Confirmed lymphoma with AIDS carriers (n = 8) were
       screened by proton MR H-1 spectra for PCr, ATP, Pi, PDE and PDM peaks.
       Results show the energy loss in tissue represented by less peak heights
       of phospho- mono- and di- esters, PCr, lactate aspartate and glutamate
       but increased peaks of carnosine, alanine and creatine after therapy.
       AIDS with lymphoma represents tissue higher oxidation and energy
       depletion. After cisplatin therapy, energy loss and tissue metabolites
       flux is normalized. Phopholipids seem to be effected significantly in
       AIDS. We conclude that NMR provides an opportunity to monitor the
       metabolite flux after AIDS drug therapy for treatment efficacy in
       complete non invasive manner.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/*PHYSIOPATHOLOGY
       Cisplatin/ADVERSE EFFECTS/THERAPEUTIC USE  Energy Metabolism/DRUG
       EFFECTS/*PHYSIOLOGY  Human  Lymphoma, AIDS-Related/DRUG
       THERAPY/*PHYSIOPATHOLOGY  Nuclear Magnetic Resonance/*METHODS
       Oxidation-Reduction  Phosphates/METABOLISM  Phospholipids/METABOLISM
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).