Document 2998
 DOCN  M94A2998
 TI    Clinical regression and lack of progression non-Hodgkin's lymphoma
       (Burkitt type) during treatment with ganciclovir (GCV) in a HIV (+)
       patient with cytomegalovirus retinitis.
 DT    9412
 AU    Luna N; Bistoni A; David DO; Rawson Hospital, Cordoba, Argentina.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):177 (abstract no. PB0135). Unique
       Identifier : AIDSLINE ICA10/94369577
 AB    OBJECTIVE: To report a case of clinical regression and lack of
       progression on a Non-Hodgkin's Lymphoma (Burkitt type) during treatment
       with Ganciclovir (GCV) in a HIV (+) patients with cytomegalovirus
       retinitis. CASE REPORT: A 35 years old patient, HIV(+), stage C3 (CDC),
       with a facial tumor that modifies the face is reported. The physical
       examination revealed a friable tumoral mass in both nasal cavities.
       Biopsy and immunohistochemical tests confirmed Burkitt Lymphoma.
       Opthalmologic control revealed cytomegalovirus retinitis. Brain, thorax
       and abdomen computed tomographic scaning did not show any evidence of
       others tumoral masses. He was receiving antiretroviral therapy with DDI
       before the tumor appeared as regular treatment for the AIDS, during the
       development of the reported tumor he received acyclovir with no avail.
       Treatment with GCV 10 mg/kg/d during 21 days was started followed by 5
       mg/kg/d 3x/week and IV gammaglobulin 3 gr q4 weeks. At present retinitis
       did not show any clinical sign of recurrence after 3 weeks of treatment.
       There was a reduction of the tumor and it has not progressed in 3
       months. CONCLUSIONS: Treatment with Ganciclovir was safe and able to
       reduce the tumor mass in a patient with Burkitt Lymphoma.
 DE    Adult  Burkitt's Lymphoma/*DRUG THERAPY  Case Report  Combined Modality
       Therapy  Cytomegalovirus Retinitis/*DRUG THERAPY  Didanosine/THERAPEUTIC
       USE  Dose-Response Relationship, Drug  Drug Administration Schedule
       Ganciclovir/*THERAPEUTIC USE  Human  HIV Seropositivity/*DRUG THERAPY
       Immunization, Passive  Lymphoma, AIDS-Related/*DRUG THERAPY  Male  Nose
       Neoplasms/*DRUG THERAPY  MEETING ABSTRACT

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