Document 3021
 DOCN  M94A3021
 TI    Presentation of pulmonary Kaposi sarcoma.
 DT    9412
 AU    Huang L; Schnapp LM; Goodman PC; Hopewell PC; Stansell JD; San Francisco
       General Hospital, University of California, 94110.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):171 (abstract no. PB0110). Unique
       Identifier : AIDSLINE ICA10/94369554
 AB    OBJECTIVE: Describe the clinical characteristics and presentation of
       pulmonary Kaposi sarcoma (KS). METHODS: Retrospective chart review of
       pulmonary KS cases diagnosed by bronchoscopy at San Francisco General
       Hospital from 1985-1993. RESULTS: During the 9 year review period, 200
       cases of pulmonary KS were diagnosed at San Francisco General Hospital.
       Ninety-one medical records were available for review. All individuals
       were HIV-infected males and 70% were caucasian. Risk factors for HIV
       were: homosexual/bisexual (71%), homosexual/bisexual and intravenous
       drug use (22%), heterosexual contact (3%), intravenous drug use (2%),
       and unknown (1%). KS was the AIDS-defining diagnosis in 60%. At
       presentation, the known extent of KS was: cutaneous and oropharyngeal
       (53%), cutaneous alone (27%), oropharyngeal alone (3%), and GI alone
       (1%). Symptoms included: cough (90%), dyspnea (84%), fever (65%), and
       hemoptysis (24%). Mean laboratory values were: CD4 count = 54 mm3,
       alveolar-arterial difference = 59 mm Hg, white blood cell count = 4.5
       K/microL, and serum lactate dehydrogenase = 299 IU/L. Chest radiograph
       findings included: interstitial infiltrates (86%), pleural effusions
       (54%), nodules (36%), and adenopathy (21%). At bronchoscopy, 50% had
       diffuse endobronchial KS lesions. Co-existent pulmonary infections
       included: PCP (22%), tuberculosis (2%), and cryptococcus (2%). Fourteen
       patients (15%, 95% CI 8%-22%) had pulmonary KS without evidence of
       mucocutaneous disease. Of these, 5 had diffuse and 9 had limited
       pulmonary KS. PCP was present in 2 of the 5 cases with diffuse and 6 of
       the 9 cases with limited pulmonary KS. DISCUSSION: This is the largest
       reported series of pulmonary KS. This review represents a selected
       population of patients who underwent bronchoscopy for respiratory
       symptoms and abnormal chest radiographs. In previous reports, the
       incidence of isolated pulmonary KS ranged from 5-7%. In our series,
       isolated pulmonary KS was present in 14 of the 91 patients (15%). Eight
       of these 14 were diagnosed with concomitant PCP as a cause of their
       presentation.
 DE    Acquired Immunodeficiency Syndrome/*DIAGNOSIS  AIDS-Related
       Opportunistic Infections/DIAGNOSIS  Bisexuality  Bronchoscopy
       Diagnosis, Differential  Female  Homosexuality  Human  Lung
       Neoplasms/*DIAGNOSIS  Male  Neoplasms, Multiple Primary/DIAGNOSIS
       Retrospective Studies  Risk Factors  Sarcoma, Kaposi's/*DIAGNOSIS
       Substance Abuse, Intravenous/COMPLICATIONS  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).