Document 0257
 DOCN  M9550257
 TI    Plasma cobalamin levels affect information processing speed in a
       longitudinal study of HIV-1 disease.
 DT    9505
 AU    Shor-Posner G; Morgan R; Wilkie F; Eisdorfer C; Baum MK; Department of
       Epidemiology, University of Miami (Fla) School of; Medicine.
 SO    Arch Neurol. 1995 Feb;52(2):195-8. Unique Identifier : AIDSLINE
       MED/95150861
 AB    OBJECTIVE: To determine whether information processing speed is
       influenced by change in plasma cobalamin status in human
       immunodeficiency virus type 1 disease. DESIGN: A longitudinal study,
       using autoregression, to evaluate the relationship between plasma
       cobalamin status and change in information processing speed assessed by
       Posner Letter Matching, Sternberg Short-Term Memory Search, Figure
       Visual Scanning and Discrimination of Pictures, and continuous paired
       associates learning tasks. SETTING: University of Miami (Fla) School of
       Medicine from fall 1987 through summer 1991. PARTICIPANTS: Eighty-four
       human immunodeficiency virus type 1-infected homosexual men aged 20 to
       55 years. None of the subjects displayed acquired immunodeficiency
       syndrome-defining symptoms at baseline; over the course of the study,
       9.5% progressed to acquired immunodeficiency syndrome. MAIN OUTCOME
       MEASURES: Biochemical measurement of plasma cobalamin; performance on
       information processing speed tasks. RESULTS: Significant improvement in
       the Posner Letter Matching NI-PI (Name Identity minus Physical Identity)
       differential was associated with becoming cobalamin adequate or
       remaining adequate. Becoming cobalamin deficient, in contrast, was
       associated with a significant decline in the speed of accessing
       overlearned name codes. CONCLUSION: Normalization of plasma cobalamin
       inadequacy in human immunodeficiency virus type 1 disease may provide
       significant improvement in the speed of retrieving overlearned
       information from long-term memory.
 DE    Adult  Human  HIV Infections/*BLOOD/*PSYCHOLOGY  Longitudinal Studies
       Male  *Mental Processes  Middle Age  Neuropsychological Tests  Support,
       U.S. Gov't, P.H.S.  Vitamin B 12/*BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).