Document 0260
 DOCN  M9550260
 TI    Clinical and epidemiologic features of infection with Mycobacterium
       genavense. Swiss HIV Cohort Study.
 DT    9505
 AU    Pechere M; Opravil M; Wald A; Chave JP; Bessesen M; Sievers A; Hein R;
       von Overbeck J; Clark RA; Tortoli E; et al; Division of Infectious
       Diseases, Hopital Cantonal Universitaire,; Geneva, Switzerland.
 SO    Arch Intern Med. 1995 Feb 27;155(4):400-4. Unique Identifier : AIDSLINE
       MED/95150747
 AB    OBJECTIVES: To characterize clinical and epidemiologic features of
       infections with Mycobacterium genavense. DESIGN: Case series and
       case-control studies. Patients with M genavense were compared with two
       control groups: CD4 controls were matched on the basis of CD4 counts,
       and Mycobacterium avium-intracellulare complex controls had disseminated
       infection with M avium-intracellulare complex. RESULTS: Fifty-four
       patients with disseminated infections caused by M genavense were found,
       from Europe (37), North America (15), and Australia (two). All were
       infected with human immunodeficiency virus. The median CD4 count was
       0.016 x 10(9)/L (16/mm3) (range, 0.001 to 0.082 x 10(9)/L). Eighty-seven
       percent had fever and weight loss, 44% had diarrhea, 43% had
       splenomegaly, 39% had hepatomegaly, and 72% had anemia. In Swiss
       university hospitals, M genavense was responsible for 12.8% of
       nontuberculous disseminated mycobacterial infections in patients with
       human immunodeficiency virus from 1990 to 1992. The median survival was
       190 days after the first isolation of M genavense. Among the patients
       who had been treated with at least two antimycobacterial drugs for 1
       month or more, median survival was 263 days (95% confidence interval,
       144 to 382 days), compared with 81 days (95% confidence interval, 73 to
       89 days) for those not treated (P = .0009). Survival in patients with M
       genavense was similar to the survival of M avium-intracellulare complex
       controls. However, patients with similar CD4 counts (CD4 controls)
       survived longer (median, 342 days; 95% confidence interval, 269 to 415
       days; P < .0003). CONCLUSIONS: Infection with M genavense may be
       responsible for more than 10% of disseminated nontuberculous
       mycobacterial infections in patients with human immunodeficiency virus
       infection. Its clinical presentation and response to treatment are
       similar to those of infection with M avium-intracellulare complex.
 DE    Adolescence  Adult  Australia/EPIDEMIOLOGY  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/DRUG THERAPY/  *EPIDEMIOLOGY  Case-Control Studies
       Child  CD4 Lymphocyte Count  Europe/EPIDEMIOLOGY  Female  Human  Life
       Tables  Male  Middle Age  Mycobacterium avium Complex  Mycobacterium
       avium-intracellulare Infection/EPIDEMIOLOGY  Mycobacterium Infections,
       Atypical/*DIAGNOSIS/DRUG THERAPY/  *EPIDEMIOLOGY  North
       America/EPIDEMIOLOGY  Survival Rate  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).