Document 0267
 DOCN  M9550267
 TI    Intestinal microsporidiosis. Report of five cases.
 DT    9505
 AU    Sun T; Kaplan MH; Teichberg S; Weissman G; Smilari T; Urmacher C;
       Department of Laboratories, Medicine and Pediatrics, North Shore;
       University Hospital, Cornell University Medical College,; Manhasset, NY
       11030.
 SO    Ann Clin Lab Sci. 1994 Nov-Dec;24(6):521-32. Unique Identifier :
       AIDSLINE MED/95150449
 AB    Five cases of intestinal microsporidiosis are reported, including one
       case of a heterosexual female acquired immunodeficiency syndrome (AIDS)
       patient, three homosexual males, and one bisexual male AIDS patients
       with detailed description of their clinical course. These five cases
       underscore the severity of immunodeficiency in patients with
       microsporidiosis. All patients had multiple opportunistic infections and
       a CD4 cell count below 100/microliters long before diarrhea developed.
       This is the first kinetic study of helper T-lymphocytes in cases of
       microsporidiosis. Diagnosis was made by duodenal biopsies stained with
       Brown and Brenn or Gram-Weigert technique (confirmed by electron
       microscopy) and by stool smears stained with a modified trichrome
       technique. However, the best preparation was plastic sections stained
       with toluidine blue, which demonstrated both the spores and plasmodia
       clearly. In our evaluation, Giemsa stain was also acceptable for
       identification of microsporidian spores in both intestinal biopsies and
       stool smears, but there was a failure to identify the organism on
       hematoxylin and eosin, acid-fast, periodic acid-Schiff, and Gomeri's
       methenamine silver stained preparations. Therapeutic attempts using
       albendazole, metronidazole, octreotide, and zidovudine (AZT) failed to
       eradicate microsporidia in these patients.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/IMMUNOLOGY/
       *PARASITOLOGY  Adult  Animal  Biopsy  Case Report  CD4 Lymphocyte Count
       Diarrhea/COMPLICATIONS/*PARASITOLOGY  Duodenum/PATHOLOGY/PARASITOLOGY
       Feces/PARASITOLOGY  Female  Homosexuality, Male  Human  Male
       Microscopy, Electron  Microspora Infections/DRUG
       THERAPY/PATHOLOGY/*PARASITOLOGY  Microsporida/*ISOLATION & PURIF  Middle
       Age  JOURNAL ARTICLE

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