Document 0283
 DOCN  M9550283
 TI    Absence of HTLV-I DNA sequences in cutaneous T-cell lymphoma/mycosis
       fungoides.
 DT    9505
 AU    Lapis P; Freeman J; Bitter MA; Golitz LE; Department of Pathology and
       Dermatology, University of Colorado; Health Sciences Center, Denver.
 SO    Acta Morphol Hung. 1992;40(1-4):249-55. Unique Identifier : AIDSLINE
       MED/95149755
 AB    Recently, the presence of deleted forms of the HTLV-I provirus was
       described in 6 out of 6 cases of CTCL. We investigated whether the
       presence of these viral genomes could be verified in 20 patients with
       CTCL using the polymerase chain reaction (PCR) and Southern blot
       analysis. Only one of the 20 cases showed a band corresponding to the pX
       region of HTLV-I. These data indicate that in the majority of CTCL
       cases, sequences closely related to HTLV-I are not present, or their
       copy number is below the limit of detection employed in this study.
 DE    Base Sequence  Blotting, Southern  DNA, Viral/*ANALYSIS/GENETICS  Human
       HTLV-I/GENETICS/*ISOLATION & PURIF  Lymphoma, T-Cell,
       Cutaneous/*VIROLOGY  Molecular Sequence Data  Mycosis
       Fungoides/*VIROLOGY  Polymerase Chain Reaction  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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