Document 0285
 DOCN  M9550285
 TI    Parkinson's disease and immunological abnormalities: increase of HLA-DR
       expression on monocytes in cerebrospinal fluid and of CD45RO+ T cells in
       peripheral blood.
 DT    9505
 AU    Fiszer U; Mix E; Fredrikson S; Kostulas V; Link H; Institute of
       Psychiatry and Neurology, Warsaw, Poland.
 SO    Acta Neurol Scand. 1994 Sep;90(3):160-6. Unique Identifier : AIDSLINE
       MED/95149672
 AB    The etiology of Parkinson's disease is mainly unknown. Immune
       abnormalities have been described, but the cause of such abnormalities
       has not been resolved. We examined by two-colour flow cytometry HLA-DR
       antigen expression on monocytes from cerebrospinal fluid (CSF) and blood
       and, moreover, lymphocyte subpopulations (CD4+ CD45RO+, CD4+ CD45RA+,
       CD8+ CD11b+high) in peripheral blood from patients with Parkinson's
       disease compared with age-matched patients with other neurological
       diseases (OND) and tension headache. We found higher HLA-DR expression
       on CSF monocytes compared with blood monocytes. This difference was
       restricted to Parkinson's disease patients. T helper cell analysis
       revealed a decreased percentage of CD45RA+ naive and an increased
       percentage of CD45RO+ memory T cell subset from CD4+ T cells in
       peripheral blood of patients with Parkinson's disease compared with
       patients with tension headache. The proportions of CD8+ CD11b+high
       suppressor T cells remained unchanged, among the three patient groups
       compared. A selective loss of CD4+ CD45RA+ cells, previously observed in
       diseases like multiple sclerosis and Down's syndrome as compared with
       healthy controls suggests a common immunological abnormality in
       neurological disorders.
 DE    Adult  Aged  Aged, 80 and over  Antigens, CD45/*BLOOD  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female
       Flow Cytometry  Headache/DIAGNOSIS/IMMUNOLOGY  Human  HLA-DR
       Antigens/*CEREBROSPINAL FLUID  Leukocyte Count  Macrophage-1
       Antigen/BLOOD  Male  Middle Age  Monocytes/*IMMUNOLOGY  Nervous System
       Diseases/DIAGNOSIS/IMMUNOLOGY  Parkinson Disease/DIAGNOSIS/*IMMUNOLOGY
       Sex Factors  Support, Non-U.S. Gov't  T-Lymphocyte Subsets/*IMMUNOLOGY
       JOURNAL ARTICLE

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