Document 0286
 DOCN  M9550286
 TI    Phenotypic analysis of cerebrospinal fluid cells over the course of Lyme
       meningoradiculitis.
 DT    9505
 AU    Sindern E; Malin JP; Department of Neurology, Ruhr University, Kliniken
       Bergmannsheil,; Bochum, Germany.
 SO    Acta Cytol. 1995 Jan-Feb;39(1):73-5. Unique Identifier : AIDSLINE
       MED/95149627
 AB    Cytologic cerebrospinal fluid abnormalities that most distinctly point
       to the diagnosis of Lyme meningoradiculitis are pronounced mononuclear
       pleocytosis composed mainly of T lymphocytes, large amounts of plasma
       cells and IgM-positive B cells. In this study, repeat examinations
       revealed decreasing cell numbers and almost normal cell counts 100-130
       days after the onset. B cells persisted over the whole observation
       period in five of six patients and were not related to any clinical
       symptoms or signs indicative of persistent meningitis or central nervous
       system involvement. The CD4/CD8 ratio of the helper/inducer and
       suppressor/cytotoxic lymphocyte subsets declined in all the patients
       after antibiotic treatment. It might be useful as a marker of the
       disease activity.
 DE    Adult  Aged  Antibodies, Bacterial/BLOOD  Antibodies,
       Monoclonal/IMMUNOLOGY  B-Lymphocytes/IMMUNOLOGY/PATHOLOGY  Borrelia
       burgdorferi/IMMUNOLOGY  Cell Count  Central Nervous
       System/CHEMISTRY/METABOLISM  Cerebrospinal Fluid/*CYTOLOGY/IMMUNOLOGY
       CD4-CD8 Ratio  Female  Follow-Up Studies  Human
       Immunoglobulins/BIOSYNTHESIS/BLOOD/CEREBROSPINAL FLUID  Lyme
       Disease/IMMUNOLOGY/*PATHOLOGY  Male  Meningitis,
       Bacterial/IMMUNOLOGY/*PATHOLOGY  Middle Age  Phenotype  Plasma
       Cells/IMMUNOLOGY/PATHOLOGY  Polyradiculoneuritis/IMMUNOLOGY/*PATHOLOGY
       T-Lymphocytes/IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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