Document 0300
 DOCN  M9550300
 TI    The effectiveness of interventions on incubation of AIDS as measured by
       secular increases within a population.
 DT    9505
 AU    Hoover DR; Munoz A; He Y; Taylor JM; Kingsley L; Chmiel JS; Saah A;
       Department of Epidemiology, Johns Hopkins School of Public; Health,
       Baltimore, MD 21205.
 SO    Stat Med. 1994 Oct 15-30;13(19-20):2127-39. Unique Identifier : AIDSLINE
       MED/95149007
 AB    Methods are developed to estimate and test for the impact of
       intervention use on a population's survival function (time to AIDS).
       Each participant's history is divided into J + 1 components: omega 0
       occurring before the intervention is available and omega 1 to omega J
       occurring later, as the intervention becomes successively more
       available. Distribution free truncated Kaplan-Meier models based on time
       since exposure fit separately to the risk sets/outcomes in omega 0 to
       omega J directly show the changing patterns of survival. Multivariate
       proportional hazards models can be used to adjust for covariates.
       Application of these methods indicates that availability of proven
       anti-AIDS interventions may have delayed time to AIDS by 8 months in an
       educated HIV-1 infected homosexual cohort with good access to medical
       care.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/MORTALITY/  *THERAPY
       Age of Onset  Cohort Studies  Disease Progression  Disease-Free Survival
       Homosexuality, Male  Human  HIV
       Infections/EPIDEMIOLOGY/MORTALITY/*THERAPY  HIV
       Seropositivity/EPIDEMIOLOGY  Male  *Models, Statistical  Multicenter
       Studies  Multivariate Analysis  Proportional Hazards Models  Statistics,
       Nonparametric  Support, U.S. Gov't, P.H.S.  Time Factors  Treatment
       Outcome  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).