Document 0304
 DOCN  M9550304
 TI    A model for AIDS pathogenesis.
 DT    9505
 AU    Schenzle D; Department of Medical Biometry, University of Tubingen,
       Germany.
 SO    Stat Med. 1994 Oct 15-30;13(19-20):2067-79. Unique Identifier : AIDSLINE
       MED/95149003
 AB    The idea is put forward and analysed numerically, that within an
       infected person HIV evolves to increase its reproductivity within the
       population of CD4+ cells. A mathematical model predicts initial viremia
       and CD4+ cell drop after HIV infection and thereafter a slow progressive
       decline in the number of CD4+ cells, although for an extended period HIV
       is kept at a relatively low level by an active immune response. The time
       span T until the number of CD4+ cells falls below 20 per cent of its
       normal value depends on several model parameters. Assuming Gaussian
       distributions for these parameters, the model predicts a distribution
       function for T which resembles the observed distribution function for
       the incubation period to AIDS.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Antibody Affinity
       Antigens, CD4  Binding Sites, Antibody  Disease Progression  Human  HIV
       Infections/GENETICS/*IMMUNOLOGY/TRANSMISSION  Immunity,
       Cellular/PHYSIOLOGY  Lymphopenia/*IMMUNOLOGY  *Models, Biological
       Mutation/IMMUNOLOGY  Poisson Distribution  Support, U.S. Gov't, P.H.S.
       T-Lymphocytes, Helper-Inducer/*IMMUNOLOGY  Time Factors  Viremia  Virus
       Latency/*IMMUNOLOGY  Virus Replication/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).