Document 0305
 DOCN  M9550305
 TI    Marker values at the time of an AIDS diagnosis.
 DT    9505
 AU    Taylor JM; Kim DK; Department of Biostatistics, University of
       California, Los; Angeles 90024-1772.
 SO    Stat Med. 1994 Oct 15-30;13(19-20):2059-66. Unique Identifier : AIDSLINE
       MED/95149002
 AB    In this paper statistical methods are proposed to estimate the
       distribution of a CD4 T-cell number at the time of a clinical AIDS
       endpoint from serial measurements of CD4 T-cell values in a cohort
       study. The statistical formulation of the problem is that of survival
       analysis with interval censored data, but in which the endpoints are
       obtained with measurement error. A measurement error likelihood is
       developed, assuming normality of the CD4 distribution at AIDS. A maximum
       likelihood estimation procedure and a Gibbs sampling approach are
       implemented.
 DE    Acquired Immunodeficiency Syndrome/DIAGNOSIS/*EPIDEMIOLOGY  Bias
       (Epidemiology)  Cohort Studies  *CD4-Positive T-Lymphocytes
       Homosexuality, Male  Human  HIV Infections/DIAGNOSIS/*EPIDEMIOLOGY
       Likelihood Functions  Los Angeles/EPIDEMIOLOGY  Male  *Models,
       Statistical  Support, U.S. Gov't, P.H.S.  *Survival Analysis  Time
       Factors  JOURNAL ARTICLE

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