Document 0308
 DOCN  M9550308
 TI    The effect of covariates on the induction time of AIDS using improved
       imputation of exact seroconversion times.
 DT    9505
 AU    Gauvreau K; Degruttola V; Pagano M; Bellocco R; Harvard School of Public
       Health, Department of Biostatistics,; Boston, Massachusetts 02115.
 SO    Stat Med. 1994 Oct 15-30;13(19-20):2021-30. Unique Identifier : AIDSLINE
       MED/95148999
 AB    This paper explores the effects of covariates such as age, gender,
       chronological time of seroconversion, and mode of virus transmission on
       the interval between HIV seroconversion and the development of AIDS. For
       many cohorts which are available to provide information about such
       effects, both the time of seroconversion and the time of onset of AIDS
       may be right- or interval-censored. To analyse these doubly-censored
       data, we propose a method in which we first estimate the marginal
       distribution of the chronological time of seroconversion and use this
       distribution to impute the seroconversion time for each subject.
       Subsequently, we estimate the distribution of induction times
       conditional on the seroconversion distribution. We apply this technique
       to a cohort of HIV seropositive subjects recruited from various
       outpatient facilities throughout Italy and show that age at
       seroconversion has the greatest effect on induction time.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  Adult  Age of Onset
       Cohort Studies  Female  Homosexuality  Human  HIV
       Infections/DIAGNOSIS/EPIDEMIOLOGY/TRANSMISSION  *HIV
       Seropositivity/*EPIDEMIOLOGY  Italy/EPIDEMIOLOGY  Likelihood Functions
       Male  *Models, Biological  Population Surveillance/*METHODS  Sex
       Behavior  Sex Factors  Substance Abuse, Intravenous  Support, U.S.
       Gov't, P.H.S.  Time Factors  JOURNAL ARTICLE

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       protected by Copyright Law (Title 17, U.S.Code).