Document 0359
 DOCN  M9550359
 TI    Differences in human immunodeficiency virus type 1 V3 sequences from
       patients with and without AIDS dementia complex.
 DT    9505
 AU    Kuiken CL; Goudsmit J; Weiller GF; Armstrong JS; Hartman S; Portegies P;
       Dekker J; Cornelissen M; Department of Virology, Academic Medical
       Centre, Amsterdam, The; Netherlands.
 SO    J Gen Virol. 1995 Jan;76 ( Pt 1):175-80. Unique Identifier : AIDSLINE +
 AB    Paired serum and cerebrospinal fluid (CSF) samples from 10 AIDS patients
       with and 10 without AIDS dementia complex (ADC) were studied, in an
       attempt to uncover ADC-associated variation in V3 sequences. Sequences
       were obtained from four of the patients with and eight of those without
       ADC. Comparison of the sequences using a resampling technique revealed a
       significant ADC-associated difference occurring at several amino acid
       positions. Results from serum and CSF sequences were comparable. These
       differences may indicate that the virus found in ADC and that in non-ADC
       patients have different biological properties. Comparison of serum
       versus CSF sequences within samples from both ADC and non-ADC patients,
       using the same resampling technique, revealed no clear distinctions. In
       some patients, the sequence populations in serum and CSF were completely
       distinct, while in others, there was no difference in distribution.
       These patterns were not associated with ADC.
 DE    Acquired Immunodeficiency Syndrome/*VIROLOGY  Amino Acid Sequence  AIDS
       Dementia Complex/BLOOD/CEREBROSPINAL FLUID/*VIROLOGY  Human  HIV
       Envelope Protein gp120/*CHEMISTRY  HIV-1/*CHEMISTRY  Molecular Sequence
       Data  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).