Document 0365
 DOCN  M9550365
 TI    Sexually transmitted diseases and human immunodeficiency virus control
       in Malawi: a field study of genital ulcer disease.
 DT    9505
 AU    Behets FM; Liomba G; Lule G; Dallabetta G; Hoffman IF; Hamilton HA;
       Moeng S; Cohen MS; Department of Medicine, University of North Carolina,
       Chapel Hill; 27599.
 SO    J Infect Dis. 1995 Feb;171(2):451-5. Unique Identifier : AIDSLINE
       MED/95146799
 AB    Men with genital ulcer disease (GUD) attending a clinic in Malawi were
       evaluated and treated with one of five drug regimens. Haemophilus
       ducreyi was isolated from 204 (26.2%) of 778 patients. Of 677 men, 198
       (29.2%) had treponemes detected in ulcer material by direct
       immunofluorescence or had rapid plasma reagin reactivity of > or = 1:8.
       Human immunodeficiency virus type 1 (HIV-1) seroprevalence was 58.9%
       overall and 75.8% among patients reporting a history of GUD (P < .001).
       By logistic regression analysis, HIV-1 seropositivity was shown to
       impair ulcer healing (P = .003). Treatment failure rates for
       culture-proven chancroid were 19% for trimethoprim-sulfamethoxazole,
       12.9% and 7.4%, respectively, for low- and high-dose erythromycin
       regimens, and 8.3% and 0, respectively, for low- and high-dose
       ciprofloxacin regimens. Herpes antigen was detected by EIA in 6 (23.1%)
       of 26 nonhealing ulcers. In Malawi, GUD should be managed as a syndrome
       to assure treatment of both syphilis and chancroid.
 DE    Chancroid/DRUG THERAPY/*EPIDEMIOLOGY  Ciprofloxacin/THERAPEUTIC USE
       Erythromycin/THERAPEUTIC USE  Genital Diseases, Male/DRUG
       THERAPY/*EPIDEMIOLOGY  Human  HIV Infections/*PREVENTION & CONTROL
       Malawi/EPIDEMIOLOGY  Male  Penicillin G, Benzathine  Skin Ulcer/DRUG
       THERAPY/*EPIDEMIOLOGY  Sulfamethoxazole/THERAPEUTIC USE  Support, U.S.
       Gov't, Non-P.H.S.  Syphilis/DRUG THERAPY/*EPIDEMIOLOGY
       Trimethoprim/THERAPEUTIC USE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).